Joseph EK, Levine JD (2010) Hyperalgesic priming is restricted to isolectin B4-positive nociceptors. Neuroscience 169(1):431-435. doi: 10.1016/j.neuroscience.2010.04.082
Summary: Hyperalgesic priming is an injury that induces a chronic pain state marked by the presence of inflammatory cytokines. The authors evaluated which populations of nociceptors are involved in the priming process. Rats that received 3.2 µg intrathecal injections of IB4-SAP (Cat. #IT-10) failed to establish priming. Acute mechanical hyperalgesia could still be induced, indicating that IB4+ nociceptors are necessary for priming, but a different nociceptor group is involved with nociceptor sensitization.
Related Products: IB4-SAP (Cat. #IT-10)