Marques-Lopes J, Pinho D, Albino-Teixeira A, Tavares I (2010) The hyperalgesic effects induced by the injection of angiotensin II into the caudal ventrolateral medulla are mediated by the pontine A(5) noradrenergic cell group. Brain Res 1325:41-52. doi: 10.1016/j.brainres.2010.02.043
Summary: Injection of angiotensin II into the caudal ventrolateral medulla (CVLM) has been shown to induce angiotensin type 1 receptor-mediated hyperalgesia. Here the authors lesioned the pontine A5 cell group with anti-DBH-SAP (Cat. #IT-03) to evaluate the role of these neurons in this model. Rats received a 1.1 µg injection of anti-DBH-SAP into the CVLM. Behavioral responses indicate that loss of noradrenergic neurons in the CVLM partially prevented angiotensin II-induced hyperalgesia.
Related Products: Anti-DBH-SAP (Cat. #IT-03)