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  4. Targeted ablation of cardiac sympathetic neurons reduces the susceptibility to ischemia-induced sustained ventricular tachycardia in conscious rats.

Targeted ablation of cardiac sympathetic neurons reduces the susceptibility to ischemia-induced sustained ventricular tachycardia in conscious rats.

Lujan HL, Palani G, Zhang L, Dicarlo SE (2010) Targeted ablation of cardiac sympathetic neurons reduces the susceptibility to ischemia-induced sustained ventricular tachycardia in conscious rats. Am J Physiol Heart Circ Physiol 298:H1330-H1339. doi: 10.1152/ajpheart.00955.2009

Summary: It has been shown that reduction of cardiac sympathetic activity protects against ventricular tachy-arrhythmias, which are the leading cause of death in industrially developed countries. Rats received 10 µg injections of CTB-SAP (Cat. #IT-14) into each stellate ganglia. Using comparison of ventricular tachycardia onset times after coronary artery occlusion it was found that lesioned rats were less susceptible to tachycardia events.

Related Products: CTB-SAP (Cat. #IT-14)

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