1. Home
  2. Knowledge Base
  3. References
  4. Substance P neurotransmission and violent aggression: the role of tachykinin NK(1) receptors in the hypothalamic attack area.

Substance P neurotransmission and violent aggression: the role of tachykinin NK(1) receptors in the hypothalamic attack area.

Halasz J, Zelena D, Toth M, Tulogdi A, Mikics E, Haller J (2009) Substance P neurotransmission and violent aggression: the role of tachykinin NK(1) receptors in the hypothalamic attack area. Eur J Pharmacol 611:35-43. doi: 10.1016/j.ejphar.2009.03.050

Summary: Stimulation of the hypothalamic attack area elicits biting attacks in rats. The authors eliminated NK1 receptor-expressing neurons in this area with bilateral 6.25-ng injections of SP-SAP (Cat. #IT-07). Violent attacks were dramatically reduced while milder forms of aggression remained unchanged, indicating that these two forms of aggression are controlled via different pathways. Lesioned animals also displayed reduced anxiety-like behavior in the elevated plus-maze, suggesting a connection between the hypothalamic attack area and brain areas controlling anxiety.

Related Products: SP-SAP (Cat. #IT-07)