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  4. Severe scene learning impairment, but intact recognition memory, after cholinergic depletion of inferotemporal cortex followed by fornix transection.

Severe scene learning impairment, but intact recognition memory, after cholinergic depletion of inferotemporal cortex followed by fornix transection.

Browning PG, Gaffan D, Croxson PL, Baxter MG (2010) Severe scene learning impairment, but intact recognition memory, after cholinergic depletion of inferotemporal cortex followed by fornix transection. Cereb Cortex 20(2):282-293. doi: 10.1093/cercor/bhp097

Summary: In this work the authors investigated the link between connections carried by the fornix and cholinergic input to the inferotemporal cortex in scene learning. Monkeys received 56-64 0.02-µg injections of ME20.4-SAP (Cat. #IT-15) into the inferotemporal cortex, and entorhinal cortices. There was a marked impairment in memory for lesioned animals that also received a fornix transection, indicating a synergistic interaction between connections carried by the fornix and cholinergic input to the inferotemporal cortex for episodic memory.

Related Products: ME20.4-SAP (Cat. #IT-15)

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