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  4. Selective lesion of retrotrapezoid Phox2b-expressing neurons raises the apneic threshold in rats.

Selective lesion of retrotrapezoid Phox2b-expressing neurons raises the apneic threshold in rats.

Takakura AC, Moreira TS, Stornetta RL, West GH, Gwilt JM, Guyenet PG (2008) Selective lesion of retrotrapezoid Phox2b-expressing neurons raises the apneic threshold in rats. J Physiol 586:2975-2991. doi: 10.1113/jphysiol.2008.153163

Summary: It is thought that transcription factor Phox2b-expressing glutamatergic interneurons are involved in the activation of breathing by elevated CO2 in the central nervous system. This activation is otherwise known as the central chemoreflex. Injections of SSP-SAP (Cat. #IT-11) into the retrotrapezoid nucleus eliminated Phox2b+TH- neurons but spared other neuron classes. Several different amounts of the conjugate were used (0.15, 0.3, or 0.6 ng in 1 or 2 injections). Elimination of ≥70% of Phox2b+TH- neurons markedly attenuated the central chemoreflex.

Related Products: SSP-SAP (Cat. #IT-11)