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The pedunculopontine tegmental nucleus and the nucleus basalis magnocellularis: do both have a role in sustained attention?

Rostron CL, Farquhar MJ, Latimer MP, Winn P (2008) The pedunculopontine tegmental nucleus and the nucleus basalis magnocellularis: do both have a role in sustained attention?. BMC Neurosci 9:16. doi: 10.1186/1471-2202-9-16

Summary: This study provided further investigation into the role of the pedunculopontine tegmental nucleus (PPTg) in control of sustained attention. Rats were given 0.13 µg injections of 192-IgG-SAP (Cat. #IT-01) into the nucleus basalis magnocellularis. The immunotoxin-treated animals were compared to animals receiving ibotenate injections into the PPTg. Results suggest that ibotenate lesions cause impaired selection of conditioned response as shown by an increase in unconditioned behaviors. 192-IgG-SAP treated animals exhibited difficulty obtaining successful lever presses linked to attention.

Related Products: 192-IgG-SAP (Cat. #IT-01)