Wang Z, Wu J-L, Zhong F, Liu Y, Yu Y-Q, Sun J-J, Wang S, Li H, Zhou X-F, Hu Z-L, Dai R-P (2019) Upregulation of proBDNF in the mesenteric lymph nodes in septic mice. Neurotox Res 36(3):540-550. doi: 10.1007/s12640-019-00081-3 PMID: 31278527
Objective: To characterize the expression pattern of proBDNF in mesenteric lymph nodes (MLNs) after lipopolysaccharide (LPS) stimulation, and to investigate the association of pathogenesis of sepsis.
Summary: This study provided direct evidence that sepsis promoted the proliferation of CD3+, CD4+, and CD8+ T cells, but inhibits CD19+ B cells in the MLNs. Also, proBDNF was upregulated during the sepsis, which was mainly localized on CD3+ and CD4+ T cells in MLNs. The upregulation of proBDNF signaling and cytokines activation in the MLNs may be involved in the disease progress of sepsis.
Usage: western blot (1:2000)
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