Severino M, Pedersen AF, Trajkovska V, Christensen E, Lohals R, Veng LM, Knudsen GM, Aznar S (2007) Selective immunolesion of cholinergic neurons leads to long-term changes in 5-HT2A receptor levels in hippocampus and frontal cortex. Neurosci Lett 428:47-51. doi: 10.1016/j.neulet.2007.09.026
Summary: Changes in several neurotransmitter systems, including serotonin and 5HT2A receptors, are associated with early Alzheimer’s disease (AD). The authors gave rats intracerebroventricular injections of either 2.5 or 5 µg of 192-IgG-SAP (Cat. #IT-01) then examined both of these systems. 5HT2A receptor levels were markedly decreased in the frontal cortex and markedly increased in the hippocampus of animals lesioned with 5 µg of 192-IgG-SAP. The change in 5HT2A receptor number suggests that the AD effect stems from interaction with the cholinergic system.
Related Products: 192-IgG-SAP (Cat. #IT-01)