Author name: Kristen Hartman

Selective medial septum lesions in healthy rats induce longitudinal changes in microstructure of limbic regions, behavioral alterations, and increased susceptibility to status epilepticus

Luna-Munguia H, Gasca-Martinez D, Garay-Cortes A, Coutiño D, Regalado M, de Los Rios E, Villaseñor P, Hidalgo-Flores F, Flores-Guapo K, Benito BY, Concha L (2024) Selective medial septum lesions in healthy rats induce longitudinal changes in microstructure of limbic regions, behavioral alterations, and increased susceptibility to status epilepticus. Mol Neurobiol 61(10):1-21. doi: 10.1007/s12035-024-04069-9 PMID: 38443731 […]

Selective medial septum lesions in healthy rats induce longitudinal changes in microstructure of limbic regions, behavioral alterations, and increased susceptibility to status epilepticus Read More »

Therapeutic peptides and proteins: Stabilization challenges and biomedical applications by means of nanodelivery systems

Berselli E, Coccolini C, Tosi G, Gokce EH, Oliveira MBPP, Fathi F, Krambeck K, Suoto EB (2024) Therapeutic peptides and proteins: Stabilization challenges and biomedical applications by means of nanodelivery systems. Int J Pept Res Ther 30:15. doi: 10.1007/s10989-024-10592-z Objective: To discuss the stability problems of proteins and peptides that have driven the scientific community

Therapeutic peptides and proteins: Stabilization challenges and biomedical applications by means of nanodelivery systems Read More »

NGFR regulates stromal cell activation in germinal centers

Hernández-Barranco A, Santos V, Mazariegos MS, Caleiras E, Nogués L, Mourcin F, Léonard S, Oblet C, Genebrier S, Rossille D, Benguría A, Sanz A, Vázquez E, Dopazo A, Efeyan A, Ortega-Molina A, Cogne M, Tarte K, Peinado H (2024) NGFR regulates stromal cell activation in germinal centers. Cell Rep 43(2):113705. doi: 10.1016/j.celrep.2024.113705 PMID: 38307025 Objective:

NGFR regulates stromal cell activation in germinal centers Read More »

Engineering small protein based inhibitors and biodegraders for cytosolic delivery and targeting of the undruggable proteome

Chan A (2024) Engineering small protein based inhibitors and biodegraders for cytosolic delivery and targeting of the undruggable proteome. Univ Pennsylvania Thesis. Objective: Studying the delivery of saporin across the cell membrane encapsulated in lipid nanoparticles. Summary: Protein payloads, like saporin and others, are given negatively charged regions which create binding sites for cationic lipids

Engineering small protein based inhibitors and biodegraders for cytosolic delivery and targeting of the undruggable proteome Read More »

Streptavidin-drug conjugates streamline optimization of antibody-based conditioning for hematopoietic stem cell transplantation

Yelamali AR, Chendamarai E, Ritchey JK, Rettig MP, DiPersio JF, Persaud SP (2024) Streptavidin-drug conjugates streamline optimization of antibody-based conditioning for hematopoietic stem cell transplantation. bioRxiv 2024.02.12.579199. doi: 10.1101/2024.02.12.579199 PMID: 38405731 Objective: Use biotinylated CD45.2 antibodies conjugated to Streptavidin to target hematopoietic stem cells (HSCs) for HSC transplantation. Summary: Hematopoietic stem cell transplantation offers a

Streptavidin-drug conjugates streamline optimization of antibody-based conditioning for hematopoietic stem cell transplantation Read More »

Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: The most attractive application of nanobodies

Abdolvahab MH, Karimi P, Mohajeri N, Abedini M, Zare H (2024) Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: The most attractive application of nanobodies. Cancer Cell Int 24(1):67. doi: 10.1186/s12935-024-03259-8 PMID: 38341580 Objective: Using nanobodies to deliver saporin to breast cancer cells. Summary: Through the binding of saporin to

Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: The most attractive application of nanobodies Read More »

The effect of NK3-Saporin injection within the arcuate nucleus on puberty, the LH surge, and the response to Senktide in female sheep

Aerts EG, Griesgraber MJ, Shuping SL, Bowdridge EC, Hardy SL, Goodman RL, Nestor CC, Hileman SM (2024) The effect of NK3-Saporin injection within the arcuate nucleus on puberty, the LH surge, and the response to Senktide in female sheep. Biol Reprod 110(2):275-287. doi: 10.1093/biolre/ioad147 PMID: 37930247 Objective: To investigate the role of NKB-SAP (NK3-SAP) in

The effect of NK3-Saporin injection within the arcuate nucleus on puberty, the LH surge, and the response to Senktide in female sheep Read More »

Investigating the cytosolic delivery of proteins by lipid nanoparticles using the chloroalkane penetration assay

Wang J, Zhang S, Li Y, Xu Q, Kritzer JA (2024) Investigating the cytosolic delivery of proteins by lipid nanoparticles using the chloroalkane penetration assay. Biochemistry doi: 10.1021/acs.biochem.3c00614 PMID: 38334719 Objective: To investigate bovine serum albumin (BSA) protein encapsulation and release within polylysine/polyglutamate (PLys/PGlu) coacervates. Summary: The findings emphasize the importance of ingredient addition sequence

Investigating the cytosolic delivery of proteins by lipid nanoparticles using the chloroalkane penetration assay Read More »

Retinal response to systemic inflammation differs between sexes and neurons

Rodríguez-Ramírez KT, Norte-Muñoz M, Lucas-Ruiz F, Gallego-Ortega A, Calzaferri F, García-Bernal D, Martínez CM, Galindo-Romero C, de Los Ríos C, Vidal-Sanz M, Agudo-Barriuso M (2024) Retinal response to systemic inflammation differs between sexes and neurons. Front Immunol 15:1340013. doi: 10.3389/fimmu.2024.1340013 PMID: 38384465 Objective: To examine how systemic inflammation, induced by intraperitoneal administration of lipopolysaccharide (LPS),

Retinal response to systemic inflammation differs between sexes and neurons Read More »

Efficacy and specificity of melanopsin reporters for retinal ganglion cells

Maloney R, Quattrochi L, Yoon J, Souza R, Berson D (2024) Efficacy and specificity of melanopsin reporters for retinal ganglion cells. J Comp Neurol 532(2):e25591. doi: 10.1002/cne.25591 PMID: 38375612 Objective: To evaluate the precision and comprehensiveness of various labeling methods for intrinsically photosensitive retinal ganglion cells (ipRGCs). Summary: The authors provide a comparative analysis of

Efficacy and specificity of melanopsin reporters for retinal ganglion cells Read More »

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