Author name: Kristen Hartman

Pseudomonas Exotoxin A based toxins targeting epidermal growth factor receptor for the treatment of prostate cancer

Fischer A, Wolf I, Fuchs H, Masilamani AP, Wolf P (2020) Pseudomonas Exotoxin A based toxins targeting epidermal growth factor receptor for the treatment of prostate cancer. Toxins (Basel) 12(12):753. doi: 10.3390/toxins12120753 Summary: Refers to chimeric murine-human mAb cetuximab bound to Streptavidin-ZAP. See: Yip WL et al. Targeted Delivery and Enhanced Cytotoxicity of Cetuximab-Saporin by […]

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Behavioral, neuromorphological, and neurobiochemical effects induced by omega-3 fatty acids following basal forebrain cholinergic depletion in aged mice

Cutuli D, Landolfo E, Nobili A, De Bartolo P, Sacchetti S, Chirico D, Marini F, Pieroni L, Ronci M, D’Amelio M, D’Amato FR, Farioli-Vecchioli S, Petrosini L (2020) Behavioral, neuromorphological, and neurobiochemical effects induced by omega-3 fatty acids following basal forebrain cholinergic depletion in aged mice. Alzheimers Res Ther 12(1):150. doi: 10.1186/s13195-020-00705-3 PMID: 33198763 Related

Behavioral, neuromorphological, and neurobiochemical effects induced by omega-3 fatty acids following basal forebrain cholinergic depletion in aged mice Read More »

Reversal of object recognition memory deficit in perirhinal cortex-lesioned rats and primates and in rodent models of aging and alzheimer’s diseases.

Masmudi-Martín M, Navarro-Lobato I, López-Aranda MF, Browning PGF, Simón A-M, López-Téllez JF, Jiménez-Recuerda I, Martîn-Montañez E, Pérez-Mediavilla A, Frechilla D, Baxter MG, Khan ZU (2020) Reversal of object recognition memory deficit in perirhinal cortex-lesioned rats and primates and in rodent models of aging and alzheimer’s diseases. Neuroscience 448:287-298. doi: 10.1016/j.neuroscience.2020.08.039 Objective: To determine if Object

Reversal of object recognition memory deficit in perirhinal cortex-lesioned rats and primates and in rodent models of aging and alzheimer’s diseases. Read More »

Loss of diffuse noxious inhibitory control after traumatic brain injury in rats: A chronic issue

Irvine KA, Sahbaie P, Ferguson AR, Clark JD (2020) Loss of diffuse noxious inhibitory control after traumatic brain injury in rats: A chronic issue. Exp Neurol 333:113428. doi: 10.1016/j.expneurol.2020.113428 Objective: To confirm hypothesis that dysfunctional descending noradrenergic and serotonergic pain control circuits may contribute to the loss of diffuse noxious inhibitory control (DNIC), a critical

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Local riluzole release from a thermosensitive hydrogel rescues injured motoneurons through nerve root stumps in a brachial plexus injury rat model

Fang J, Li L, Zhai H, Qin B, Quan D, Shi E, Zhu M, Yang J, Liu X, Gu L (2020) Local riluzole release from a thermosensitive hydrogel rescues injured motoneurons through nerve root stumps in a brachial plexus injury rat model. Neurochem Res 45(11):2800-2813. doi: 10.1007/s11064-020-03120-0 Summary: The authors refer to a review by

Local riluzole release from a thermosensitive hydrogel rescues injured motoneurons through nerve root stumps in a brachial plexus injury rat model Read More »

Characterization of the renin-angiotensin system in aged cavernosal tissue and its role in penile fibrosis.

Bragina ME, Costa-Fraga F, Sturny M, Ebadi B, Ruoccolo RT, Santos RAS, Fraga-Silva RA, Stergiopulos N (2020) Characterization of the renin-angiotensin system in aged cavernosal tissue and its role in penile fibrosis. J Sex Med 17:2129–2140. doi: 10.1016/j.jsxm.2020.08.008 PMID: 32943375 Objective: To investigate local regulation of the renin-angiotensin system (RAS) in age-related erectile dysfunction (ED).

Characterization of the renin-angiotensin system in aged cavernosal tissue and its role in penile fibrosis. Read More »

Respiratory pathology in the Optn-/- mouse model of Amyotrophic Lateral Sclerosis.

McCall AL, Dhindsa JS, Pucci LA, Kahn AF, Fusco AF, Biswas DD, Strickland LM, Tseng HC, ElMallah MK (2020) Respiratory pathology in the Optn-/- mouse model of Amyotrophic Lateral Sclerosis. Respir Physiol Neurobiol 282:103525. doi: 10.1016/j.resp.2020.103525 Summary: Tongue muscle weakness results in dysarthria and dysphagia leading to recurrent aspiration, choking, and aggravation of respiratory disease.

Respiratory pathology in the Optn-/- mouse model of Amyotrophic Lateral Sclerosis. Read More »

Spinal microglia-neuron interactions in chronic pain.

Ho IHT, Chan MTV, Wu WKK, Liu X (2020) Spinal microglia-neuron interactions in chronic pain. J Leukoc Biol 108:1575-1592. doi: 10.1002/JLB.3MR0520-695R Summary: Spinal microglial activation is initiated shortly and persisted for more than 3 mo after partial sciatic nerve ligation. Intrathecal injection of Mac1-SAP, a saporin-conjugated anti-CD11b antibody to deplete microglia, abolished cold and mechanical allodynia

Spinal microglia-neuron interactions in chronic pain. Read More »

Noradrenaline signaling in the LPBN mediates amylin’s and salmon calcitonin’s hypophagic effect in male rats.

Boccia L, Le Foll C, Lutz TA (2020) Noradrenaline signaling in the LPBN mediates amylin’s and salmon calcitonin’s hypophagic effect in male rats. FASEB J 34(11):15448-15461. doi: 10.1096/fj.202001456RRR Objective: To assess the phenotype of amylin activated LPBN (lateral parabrachial nucleus) neurons, especially to confirm the CGRPergic phenotype and to uncover the specific role of NA

Noradrenaline signaling in the LPBN mediates amylin’s and salmon calcitonin’s hypophagic effect in male rats. Read More »

New Publications using Saporin conjugates

Cat. #IT-01  192-IgG-SAP Lesions of the nucleus basalis magnocellularis (Meynert) induce enhanced somatosensory responses and tactile hypersensitivity in rats. Dezawa S, Nagasaka K, Watanabe Y, & Takashima I. (2020). Exp Neurol, 335 113493. 2020/10/05.  Disruption of basal forebrain cholinergic neurons after traumatic brain injury does not compromise environmental enrichment-mediated cognitive benefits. Moschonas EH, Leary JB,

New Publications using Saporin conjugates Read More »

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