Author name: Kristen Hartman

A systematic review of oropharyngeal dysphagia models in rodents

Kim HN, Kim JY (2021) A systematic review of oropharyngeal dysphagia models in rodents. Int J Environ Res Public Health 18(9):4987. doi: 10.3390/ijerph18094987 Objective: To organize the rodent models of oropharyngeal dysphagia reported to date. Summary: Applying and analyzing the treatment in rodent models of dysphagia induced from various causes is an essential process to […]

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Comparison of the effects of two therapeutic strategies based on olfactory ensheathing cell transplantation and repetitive magnetic stimulation after spinal cord injury in female mice

Delarue Q, Robac A, Massardier R, Marie JP, Guérout N (2021) Comparison of the effects of two therapeutic strategies based on olfactory ensheathing cell transplantation and repetitive magnetic stimulation after spinal cord injury in female mice. J Neurosci Res 99(7):1835-1849. doi: 10.1002/jnr.24836 PMID: 33960512 Objective: To compare two therapeutic approaches; individual primary olfactory ensheathing cell

Comparison of the effects of two therapeutic strategies based on olfactory ensheathing cell transplantation and repetitive magnetic stimulation after spinal cord injury in female mice Read More »

Cholinergic regulation of adult hippocampal neurogenesis and hippocampus-dependent functions

Madrid LI, Jimenez-Martin J, Coulson EJ, Jhaveri DJ (2021) Cholinergic regulation of adult hippocampal neurogenesis and hippocampus-dependent functions. Int J Biochem Cell Biol 134:105969. doi: 10.1016/j.biocel.2021.105969 Summary: In this review, the authors appraise the evidence linking the contribution of cholinergic signalling to the regulation of adult hippocampal neurogenesis and hippocampus-dependent functions. Usage: A hallmark feature

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Possible contribution of cerebellar disinhibition in epilepsy

Ming X, Prasad N, Thulasi V, Elkins K, Shivamurthy VKN (2021) Possible contribution of cerebellar disinhibition in epilepsy. Epilepsy Behav 118:107944. doi: 10.1016/j.yebeh.2021.107944 Summary: The authors hypothesize that loss of inhibition from the cerebellum can lead to cortical activation and seizures. An animal study showed microinjection of SSP-SAP produced a selective ablation of hippocampal inhibitory

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Cardiac pathology in Mucopolysaccharidosis I mice: Losartan modifies ERK1/2 activation during cardiac remodeling.

Gonzalez EA, Leitão SAT, Dos Santos Soares D, Tavares AMV, Giugliani R, Baldo G, Matte U (2021) Cardiac pathology in Mucopolysaccharidosis I mice: Losartan modifies ERK1/2 activation during cardiac remodeling. J Inherit Metab Dis 44(3):740-750. doi: 10.1002/jimd.12327 PMID: 33145772 Objective: To investigate whether the pathways influenced by losartan and propranolol may modulate the cardiac remodeling

Cardiac pathology in Mucopolysaccharidosis I mice: Losartan modifies ERK1/2 activation during cardiac remodeling. Read More »

An acetylcholine-dopamine interaction in the nucleus accumbens and its involvement in ethanol’s dopamine-releasing effect.

Loftén A, Adermark L, Ericson M, Söderpalm B (2021) An acetylcholine-dopamine interaction in the nucleus accumbens and its involvement in ethanol’s dopamine-releasing effect. Addict Biol 26(3):e12959. doi: 10.1111/adb.12959 Summary: Basal extracellular levels of dopamine within the nucleus accumbens are not sustained by muscarinic acetylcholine, whereas accumbal Cholinergic interneurons-ACh are involved in mediating ethanol-induced dopamine release.

An acetylcholine-dopamine interaction in the nucleus accumbens and its involvement in ethanol’s dopamine-releasing effect. Read More »

Autosomal recessive osteopetrosis: mechanisms and treatments

Penna S, Villa A, Capo V (2021) Autosomal recessive osteopetrosis: mechanisms and treatments. Dis Model Mech 14(5):dmm048940. doi: 10.1242/dmm.048940 Summary: Autosomal recessive osteopetrosis (ARO) is a severe inherited bone disease characterized by defective osteoclast resorption or differentiation. Novel therapeutic approaches are needed for ARO patients. The authors review preclinical and proof-of-concept studies, such as gene

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Placenta: A gold mine for translational research and regenerative medicine

Pethe P, Kale V (2021) Placenta: A gold mine for translational research and regenerative medicine. Reprod Biol 21(2):100508. doi: 10.1016/j.repbio.2021.100508 Objective: To review recent studies regarding the therapeutic potential of human placenta-derived mesenchymal stromal/stem cells (hPMSCs) and their extracellular vesicles (EVs). Summary: These studies demonstrate salutary effects of hPMSC-EVs on a range of different difficult-to-treat

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Medullary noradrenergic neurons mediate hemodynamic responses to osmotic and volume challenges

Marques SM, Naves LM, Silva TME, Cavalcante KVN, Alves JM, Ferreira-Neto ML, de Castro CH, Freiria-Oliveira AH, Fajemiroye JO, Gomes RM, Colombari E, Xavier CH, Pedrino GR (2021) Medullary noradrenergic neurons mediate hemodynamic responses to osmotic and volume challenges. Front Physiol 12:649535. doi: 10.3389/fphys.2021.649535 Summary: The study sought to determine the role of noradrenergic neurons

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