Author name: Kristen Hartman

Interactions between aging and cortical cholinergic deafferentation on attention.

Burk JA, Herzog CD, Porter MC, Sarter M (2002) Interactions between aging and cortical cholinergic deafferentation on attention. Neurobiol Aging 23:467-477. doi: 10.1016/s0197-4580(01)00315-3 Summary: Trauma to forebrain cholinergic neurons is suspected to make these neurons more susceptible to future age-related loss of function. The authors tested this theory by making incomplete lesions of the basal […]

Interactions between aging and cortical cholinergic deafferentation on attention. Read More »

Depressor and tachypneic responses to chemical stimulation of the ventral respiratory group are reduced by ablation of neurokinin-1 receptor-expressing neurons.

Wang H, Germanson TP, Guyenet PG (2002) Depressor and tachypneic responses to chemical stimulation of the ventral respiratory group are reduced by ablation of neurokinin-1 receptor-expressing neurons. J Neurosci 22(9):3755-3764. doi: 10.1523/JNEUROSCI.22-09-03755.2002 Summary: The pre-Bötzinger complex is a region of the ventral respiratory group (VRG) in the brain. Injection of excitatory amino acids into this

Depressor and tachypneic responses to chemical stimulation of the ventral respiratory group are reduced by ablation of neurokinin-1 receptor-expressing neurons. Read More »

Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain.

Li X, Conklin D, Ma W, Zhu X, Eisenach JC (2002) Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain. Pain 97:117-125. doi: 10.1016/s0304-3959(02)00011-8 Summary: T62 is a thiobene compound that enhances adenosine agonist binding to the A1 receptor. Activation of the adenosine receptor has been

Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain. Read More »

Selective immunolesions of CH4 cholinergic neurons do not disrupt spatial memory in rats.

Galani R, Lehmann O, Bolmont T, Aloy E, Bertrand F, Lazarus C, Jeltsch H, Cassel JC (2002) Selective immunolesions of CH4 cholinergic neurons do not disrupt spatial memory in rats. Physiol Behav 76:75-90. doi: 10.1016/s0031-9384(02)00674-1 Summary: Lesioning of the nucleus basalis magnocellularis (NBM) with 192-Saporin (Cat. #IT-01) has produced varied cognitive effects in numerous studies.

Selective immunolesions of CH4 cholinergic neurons do not disrupt spatial memory in rats. Read More »

Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum.

Berchtold NC, Kesslak JP, Cotman CW (2002) Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum. J Neurosci Res 68(5):511-521. doi: 10.1002/jnr.10256 Summary: Brain-derived neurotrophic factor (BDNF) enhances neuron function and plasticity. The authors lesioned rats with medial septal injections of 192-Saporin (Cat #IT-01, 375 ng in 0.5 µl PBS) or OX7-SAP

Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum. Read More »

Selective lesions of rabbit extraocular muscles injected with the anti-AChR immunotoxin saporin-mAb 73

Campos EC, Schiavi C, Bolognesi A, Bellusci C, Lubelli C, Duca A, Polito L, Poulas K, Tzartos SJ, Stirpe F (2002) Selective lesions of rabbit extraocular muscles injected with the anti-AChR immunotoxin saporin-mAb 73. Curr Eye Res 24(1):58-65. doi: 10.1076/ceyr.24.1.58.5430 PMID: 12187496 Objective: Investigating the efficacy of saporin-based immunotoxins in modeling of eye and facial

Selective lesions of rabbit extraocular muscles injected with the anti-AChR immunotoxin saporin-mAb 73 Read More »

Toxin Safety

Q: You have stated that it was unlikely that saporin compounds or constituents would be excreted in urine or feces. However, you acknowledge that experimental data is lacking. Have there been any tests of animal urine or feces for saporin content? My animal care staff are concerned. A: One of the reasons that no studies

Toxin Safety Read More »

Impairments in negative patterning, but not simple discrimination learning, in rats with 192 IgG-Saporin lesions of the nucleus basalis magnocellularis.

Butt AE, Noble MM, Rogers JL, Rea TE (2002) Impairments in negative patterning, but not simple discrimination learning, in rats with 192 IgG-Saporin lesions of the nucleus basalis magnocellularis. Behav Neurosci 116(2):241-255. doi: 10.1037//0735-7044.116.2.241 Summary: 192-Saporin (Cat. #IT-01) administration to the basal forebrain has frequently been used in rats to create a model for Alzheimer’s

Impairments in negative patterning, but not simple discrimination learning, in rats with 192 IgG-Saporin lesions of the nucleus basalis magnocellularis. Read More »

Featured Article: HCRT-SAP lesion produces sleepiness while anti-DBH-SAP lesion does not

Blanco-Centurion C (2002) Featured Article: HCRT-SAP lesion produces sleepiness while anti-DBH-SAP lesion does not. Targeting Trends 3(2) Related Products: Anti-DBH-SAP (Cat. #IT-03), Orexin-B-SAP (Cat. #IT-20) Read the featured article in Targeting Trends. See Also: Blanco-Centurion CA et al. Hypocretin B-Saporin Lesions Of The Brainstem Increase Rem Sleep At Night. Neuroscience 2001 Abstracts 410.9, 2001. Society

Featured Article: HCRT-SAP lesion produces sleepiness while anti-DBH-SAP lesion does not Read More »

Shopping Cart
Scroll to Top