Nichols ML, Allen BJ, Rogers SD, Ghilardi JR, Honore P, Luger NM, Finke MP, Li J, Lappi DA, Simone DA, Mantyh PW (1999) Transmission of chronic nociception by spinal neurons expressing the substance P receptor. Science 286:1558-1561. doi: 10.1126/science.286.5444.1558 Related Products: SP-SAP (Cat. #IT-07)
ADVANCED TARGETING SYSTEMS ANNOUNCES ITS MOLECULAR NEUROSURGERY TECHNOLOGY OPENS DOOR TO PERMANENT RELIEF FOR CHRONIC PAIN SAN DIEGO, CA, NOVEMBER 18, 1999— Chronic, intractable pain afflicts millions of Americans. Pioneering new technology, called molecular neurosurgery and developed by Advanced Targeting Systems, a San Diego-based company, provides the springboard for a one-time injection of a targeted
SP-SAP as Chronic Pain Therapeutic Read More »
Kwok KHH, Law KB, Wong RNS, Yung KKL (1999) Immunolesioning of nerve growth factor p75 receptor-containing neurons in the rat brain by a novel immunotoxin: anti-p75-anti-mouse IgG-trichosanthin conjugates. Brain Res 846:154-163. doi: 10.1016/s0006-8993(99)01999-x Related Products: 192-IgG-SAP (Cat. #IT-01)
Hart S, Sarter M, Berntson GG (1999) Cholinergic inputs to the rat medial prefrontal cortex mediate potentiation of the cardiovascular defensive response by the anxiogenic benzodiazepine receptor partial inverse agonist FG 7142. Neuroscience 94(4):1029-1038. doi: 10.1016/s0306-4522(99)00269-9 Related Products: 192-IgG-SAP (Cat. #IT-01)
Hartlage-Ruebsamen M, Lippe WR, Schliebs R (1999) Cholinergic basal forebrain lesion results in reduced activity of neuronal NO synthase in hippocampal and neocortical areas of the rat brain. Neuroscience 1999 Abstracts 847.3. Society for Neuroscience, Miami, FL. Summary: Nitric oxide (NO) released by cortical neurons expressing the neuronal form of NO synthase (nNOS) is known
Silveira DC, Holmes GL, Schachter SC, Geula C, Schomer DL (1999) Increased susceptibility to flurothyl-induced generalized seizures after immunolesions to cholinergic neurons in the basal forebrain. Neuroscience 1999 Abstracts 643.7. Society for Neuroscience, Miami, FL. Summary: Intracerebroventricular (icv) injections of toxin 192 IgG-saporin produce almost complete loss of cholinergic neurons in the basal forebrain (BF)
Janni G, Lappi DA, Ohara PT, Jasmin L (1999) CTB-saporin induced demyelinating myelopathy in the rat. Neuroscience 1999 Abstracts 731.2. Society for Neuroscience, Miami, FL. Summary: In designing a rat model of demyelinating disease, we have used a newly developed neurotoxin, the B fragment of cholera toxin (CTB) linked to the potent ribosome inactivating protein
CTB-saporin induced demyelinating myelopathy in the rat. Read More »
Waite JJ (1999) Cholinergic deafferentation of the hippocampus or cortex produces differential modulation of attentional processing. Neuroscience 1999 Abstracts 754.4. Society for Neuroscience, Miami, FL. Summary: Dissociation of attentional changes produced by lesion of the cholinergic neurons in the medial septum (MS) and nucleus basalis magnocellularis (NBM) was investigated by selective lesion with the immunotoxin
Barker-Gibb ML, Einheber S, Milner TA (1999) Hippocampal Trk-A receptors are compartmentalized within axonal transport vesicle sites and present in select astrocytes. Neuroscience 1999 Abstracts 803.6. Society for Neuroscience, Miami, FL. PMID: 0 Summary: Trk-A is a high affinity transmembrane tyrosine kinase receptor which is activated by its ligand, nerve growth factor (NGF), to mediate
Secor A, Nocera R, Pang KCH (1999) GABAergic septohippocampal neurons are not necessary for spatial memory. (Poster). Neuroscience 1999 Abstracts 559.9 . Society for Neuroscience, Miami, FL. Summary: The medial septum/diagonal band of Broca (MS-DB) provides a major input to the hippocampus, and nonselective lesions of MS-DB neurons or their projections to the hippocampus impair
GABAergic septohippocampal neurons are not necessary for spatial memory. (Poster) Read More »