Author name: Kristen Hartman

Featured Article: IB4-SAP prevents axotomy-induced sprouting of Aß fibers

Pearson M (2005) Featured Article: IB4-SAP prevents axotomy-induced sprouting of Aß fibers. Targeting Trends 6(1) Related Products: IB4-SAP (Cat. #IT-10) Read the featured article in Targeting Trends. See Also: Pearson MS et al. IB4-SAP reduces IB4 staining in the spinal cord and prevents axotomy induced sprouting of Aβ fibers. Neuroscience 2004 Abstracts 858.6, 2004. Society […]

Featured Article: IB4-SAP prevents axotomy-induced sprouting of Aß fibers Read More »

Involvement of GABAergic and cholinergic medial septal neurons in hippocampal theta rhythm.

Yoder RM, Pang KC (2005) Involvement of GABAergic and cholinergic medial septal neurons in hippocampal theta rhythm. Hippocampus 15(3):381-392. doi: 10.1002/hipo.20062 Summary: It is thought that hippocampal theta rhythm (HPCθ) is involved in attention and acquisition of sensory information. The HPCθ circuit includes the medial septum/diagonal band of Broca (MSDB), which projects to the hippocampus

Involvement of GABAergic and cholinergic medial septal neurons in hippocampal theta rhythm. Read More »

ATS Seeks Strategic Partner for Chronic Pain Drug

SP SAP Drug Development /

Toxicology studies with the potential chronic pain therapeutic, SP-SAP (Substance P-Saporin) are continuing successfully. The second study will be initiated in a few months and ATS is diligently pursuing a pharmaceutical partner that can quickly bring the drug to clinical trials in humans. With the recent news of the undesirable side effects of such pain

ATS Seeks Strategic Partner for Chronic Pain Drug Read More »

Cover Article: IB4-SAP Prevents Axotomy-Induced Sprouting of Aß Fibers

News Article /

Contributed by ATS’s 2004 Society for Neuroscience Poster of the Year Award Winner:Michelle Pearson, Purdue Pharma, Discovery Research, 6 Cedar Brook Drive, Cranbury NJ 08540 Neuropathic pain results in hyperalgesia and allodynia. It has been proposed that sprouting of myelinated touch-responsive Aβ-fibers into the innervation territory of pain-sensitive C-fibers in the spinal cord contributes to

Cover Article: IB4-SAP Prevents Axotomy-Induced Sprouting of Aß Fibers Read More »

No facilitation of amphetamine- or cocaine-induced hyperactivity in adult rats after various 192 IgG-saporin lesions in the basal forebrain.

Jeltsch H, Lazarus C, Cosquer B, Galani R, Cassel JC (2004) No facilitation of amphetamine- or cocaine-induced hyperactivity in adult rats after various 192 IgG-saporin lesions in the basal forebrain. Brain Res 1029(2):259-271. doi: 10.1016/j.brainres.2004.09.053 Summary: Previous data have indicated that intracerebroventricular (icv) injections of 192-Saporin (Cat. #IT-01) induce a dramatic increase of the locomotor

No facilitation of amphetamine- or cocaine-induced hyperactivity in adult rats after various 192 IgG-saporin lesions in the basal forebrain. Read More »

The behavioral and neuroanatomical effects of IB(4)-saporin treatment in rat models of nociceptive and neuropathic pain.

Tarpley JW, Kohler MG, Martin WJ (2004) The behavioral and neuroanatomical effects of IB(4)-saporin treatment in rat models of nociceptive and neuropathic pain. Brain Res 1029(1):65-76. doi: 10.1016/j.brainres.2004.09.027 Summary: Using the fact that primary afferent neurons bind isolectin B4 (IB4), the authors injected 5 µg of IB4-SAP (Cat. #IT-10) into the sciatic nerve in the

The behavioral and neuroanatomical effects of IB(4)-saporin treatment in rat models of nociceptive and neuropathic pain. Read More »

Histamine innervation and activation of septohippocampal GABAergic neurones: Involvement of local ACh release.

Xu C, Michelsen KA, Wu M, Morozova E, Panula P, Alreja M (2004) Histamine innervation and activation of septohippocampal GABAergic neurones: Involvement of local ACh release. J Physiol 561(Pt 3):657-670. doi: 10.1113/jphysiol.2004.071712 PMID: 15486020 Related Products: 192-IgG Mouse Monoclonal, Cy3-labeled (Cat. #AB-N43FL3)

Histamine innervation and activation of septohippocampal GABAergic neurones: Involvement of local ACh release. Read More »

Sexually dimorphic effects of hippocampal cholinergic deafferentation in rats.

Jonasson Z, Cahill JF, Tobey RE, Baxter MG (2004) Sexually dimorphic effects of hippocampal cholinergic deafferentation in rats. Eur J Neurosci 20(11):3041-3053. doi: 10.1111/j.1460-9568.2004.03739.x Summary: Studies of cholinergic neuron lesions have been performed almost exclusively in male animals. In this work, the authors examined the differences of cholinergic lesions between males and females. Rats were

Sexually dimorphic effects of hippocampal cholinergic deafferentation in rats. Read More »

Transient attenuation of CO2 sensitivity after neurotoxic lesions in the medullary raphe-area in awake goats.

Hodges MR, Opansky C, Qian B, Davis S, Bonis J, Bastasic J, Leekley T, Pan LG, Forster HV (2004) Transient attenuation of CO2 sensitivity after neurotoxic lesions in the medullary raphe-area in awake goats. J Appl Physiol 97(6):2236-2247. doi: 10.1152/japplphysiol.00584.2004 Summary: The authors wished to investigate the influence medullary raphe-area neurons have on breathing. This

Transient attenuation of CO2 sensitivity after neurotoxic lesions in the medullary raphe-area in awake goats. Read More »

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