Author name: Kristen Hartman

The effect of central cholinergic and noradrenergic denervation on hippocampal sympathetic ingrowth and apoptosis-like reactivity in the rat.

Harrell LE, Parsons DS, Kolasa K (2005) The effect of central cholinergic and noradrenergic denervation on hippocampal sympathetic ingrowth and apoptosis-like reactivity in the rat. Brain Res 1033(1):68-77. doi: 10.1016/j.brainres.2004.11.021 Summary: Cholinergic denervation of the hippocampus is followed by ingrowth of peripheral sympathetic fibers originating from the superior cervical ganglion. The authors injected 1 µg […]

The effect of central cholinergic and noradrenergic denervation on hippocampal sympathetic ingrowth and apoptosis-like reactivity in the rat. Read More »

Effects of cholinergic deafferentation of the rhinal cortex on visual recognition memory in monkeys.

Turchi J, Saunders RC, Mishkin M (2005) Effects of cholinergic deafferentation of the rhinal cortex on visual recognition memory in monkeys. Proc Natl Acad Sci U S A 102(6):2158-2161. doi: 10.1073/pnas.0409708102 Summary: The rhinal cortex has been shown to play a critical role in recognition memory. The investigators examined the effect of eliminating cholinergic input

Effects of cholinergic deafferentation of the rhinal cortex on visual recognition memory in monkeys. Read More »

Hebb-Williams performance and scopolamine challenge in rats with partial immunotoxic hippocampal cholinergic deafferentation.

Marques Pereira P, Cosquer B, Schimchowitsch S, Cassel JC (2005) Hebb-Williams performance and scopolamine challenge in rats with partial immunotoxic hippocampal cholinergic deafferentation. Brain Res Bull 64(5):381-394. doi: 10.1016/j.brainresbull.2004.09.007 Summary: Much of the recent work done on the role of cholinergic neurons in the hippocampus has been focused on detecting subtle learning deficits. In this

Hebb-Williams performance and scopolamine challenge in rats with partial immunotoxic hippocampal cholinergic deafferentation. Read More »

An opposing time-dependent immune-modulating effect of the sympathetic nervous system conferred by altering the cytokine profile in the local lymph nodes and spleen of mice with type II collagen-induced arthritis.

Harle P, Mobius D, Carr DJ, Scholmerich J, Straub RH (2005) An opposing time-dependent immune-modulating effect of the sympathetic nervous system conferred by altering the cytokine profile in the local lymph nodes and spleen of mice with type II collagen-induced arthritis. Arthritis Rheum 52:1305-1313. doi: 10.1002/art.20987 Summary: In this work the authors examined the role

An opposing time-dependent immune-modulating effect of the sympathetic nervous system conferred by altering the cytokine profile in the local lymph nodes and spleen of mice with type II collagen-induced arthritis. Read More »

Targeting Tools: Anti-ChAT

ATS is pleased to present a polyclonal antibody specific for ChAT protein. Choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine (ACh) from choline and acetyl-CoA in cholinergic neurons. ChAT serves as a specific marker for cholinergic neurons in both the peripheral and central nervous systems. Dysfunction of cholinergic neurons underlies aspects of clinical

Targeting Tools: Anti-ChAT Read More »

Featured Article: IB4-SAP prevents axotomy-induced sprouting of Aß fibers

Pearson M (2005) Featured Article: IB4-SAP prevents axotomy-induced sprouting of Aß fibers. Targeting Trends 6(1) Related Products: IB4-SAP (Cat. #IT-10) Read the featured article in Targeting Trends. See Also: Pearson MS et al. IB4-SAP reduces IB4 staining in the spinal cord and prevents axotomy induced sprouting of Aβ fibers. Neuroscience 2004 Abstracts 858.6, 2004. Society

Featured Article: IB4-SAP prevents axotomy-induced sprouting of Aß fibers Read More »

Involvement of GABAergic and cholinergic medial septal neurons in hippocampal theta rhythm.

Yoder RM, Pang KC (2005) Involvement of GABAergic and cholinergic medial septal neurons in hippocampal theta rhythm. Hippocampus 15(3):381-392. doi: 10.1002/hipo.20062 Summary: It is thought that hippocampal theta rhythm (HPCθ) is involved in attention and acquisition of sensory information. The HPCθ circuit includes the medial septum/diagonal band of Broca (MSDB), which projects to the hippocampus

Involvement of GABAergic and cholinergic medial septal neurons in hippocampal theta rhythm. Read More »

ATS Seeks Strategic Partner for Chronic Pain Drug

Toxicology studies with the potential chronic pain therapeutic, SP-SAP (Substance P-Saporin) are continuing successfully. The second study will be initiated in a few months and ATS is diligently pursuing a pharmaceutical partner that can quickly bring the drug to clinical trials in humans. With the recent news of the undesirable side effects of such pain

ATS Seeks Strategic Partner for Chronic Pain Drug Read More »

Cover Article: IB4-SAP Prevents Axotomy-Induced Sprouting of Aß Fibers

Contributed by ATS’s 2004 Society for Neuroscience Poster of the Year Award Winner:Michelle Pearson, Purdue Pharma, Discovery Research, 6 Cedar Brook Drive, Cranbury NJ 08540 Neuropathic pain results in hyperalgesia and allodynia. It has been proposed that sprouting of myelinated touch-responsive Aβ-fibers into the innervation territory of pain-sensitive C-fibers in the spinal cord contributes to

Cover Article: IB4-SAP Prevents Axotomy-Induced Sprouting of Aß Fibers Read More »

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