Author name: Kristen Hartman

Host receptor-targeted therapeutic approach to counter pathogenic New World mammarenavirus infections

Hickerson BT, Daniels-Wells TR, Payes C, Clark LE, Candelaria PV, Bailey KW, Sefing EJ, Zink S, Ziegenbein J, Abraham J, Helguera G, Penichet ML, Gowen BB (2022) Host receptor-targeted therapeutic approach to counter pathogenic New World mammarenavirus infections. Nat Commun 13(1):558. doi: 10.1038/s41467-021-27949-3 PMID: 35091550 Objective: Demonstrate that a fusion protein of the antibody (ch128.1/IgG1) […]

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Antibody based delivery of toxins and other active molecules for cancer therapy

Polito L (2022) Antibody based delivery of toxins and other active molecules for cancer therapy. Biomedicines 10(2):267. doi: 10.3390/biomedicines10020267 PMID: 35203476 Summary: This introduction to studies collected in a special issue that confirmed the potential of immunotherapy for targeted therapy in different cancer models. In the near future, antibody-based therapeutic approaches could improve the outcomes

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A perspective on the applications of functionalized nanogels: promises and challenges

Pinelli F, Saadati M, Zare EN, Makvandi P, Masi M, Sacchetti A, Rossi F (2023) A perspective on the applications of functionalized nanogels: promises and challenges. International Materials Reviews 68(1):1-25. doi: 10.1080/09506608.2022.2026864 Summary: A perspective on the applications of functionalized nanogels: their features such as large surface area, ability to hold molecules, flexibility in size

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Cytokines in the Brain and Neuroinflammation: We Didn’t Starve the Fire!

Konsman JP (2022) Cytokines in the Brain and Neuroinflammation: We Didn’t Starve the Fire!. Pharmaceuticals (Basel) 15(2):140. doi: 10.3390/ph15020140 PMID: 35215252 Summary: To test the role of IL-1 receptor brain macrophages, the work of Chaskiel et al. employed IL-1 coupled to the ribosome toxin, saporin, and administered this conjugate into forebrain ventricles to effectively reduce

Cytokines in the Brain and Neuroinflammation: We Didn’t Starve the Fire! Read More »

Female-specific mechanisms of nociplastic pain in murine model

Hankerd K (2021) Female-specific mechanisms of nociplastic pain in murine model. The University of Texas Medical Branch at Galveston, Dept Neuroscience Thesis. Objective: To study nociplastic pain the authors developed a murine model in which postinjury thermal stimulation of injured area triggers the transition to a nociplastic pain state more readily in females. Summary: Postinjury

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Nonsteroidal anti-inflammatory drug (ketoprofen) delivery differentially impacts phrenic long-term facilitation in rats with motor neuron death induced by intrapleural CTB-SAP injections

Borkowski LF, Keilholz AN, Smith CL, Canda KA, Nichols NL (2021) Nonsteroidal anti-inflammatory drug (ketoprofen) delivery differentially impacts phrenic long-term facilitation in rats with motor neuron death induced by intrapleural CTB-SAP injections. Exp Neurol 347:113892. doi: 10.1016/j.expneurol.2021.113892 Objective: To determine the effect of ketoprofen delivery on enhanced phrenic long-term facilitation (pLTF) Summary: pLTF was surprisingly

Nonsteroidal anti-inflammatory drug (ketoprofen) delivery differentially impacts phrenic long-term facilitation in rats with motor neuron death induced by intrapleural CTB-SAP injections Read More »

Expression pattern of brain-derived neurotrophic factor and its associated receptors: Implications for exogenous neurotrophin application

Schulze J, Staecker H, Wedekind D, Lenarz T, Warnecke A (2022) Expression pattern of brain-derived neurotrophic factor and its associated receptors: Implications for exogenous neurotrophin application. Hear Res 413:108098. doi: 10.1016/j.heares.2020.108098 PMID: 33143996 Objective: To investigate the mechanisms of brain-derived neurotrophic factor (BDNF) in the inner ear, by analyzing the expression of mature BDNF (mBDNF),

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Mouse lung organoid responses to reduced, increased, and cyclic stretch

Joshi R, Batie MR, Fan Q, Varisco BM (2022) Mouse lung organoid responses to reduced, increased, and cyclic stretch. Am J Physiol Lung Cell Mol Physiol 322(1):L162-L173. doi: 10.1152/ajplung.00310.2020 PMID: 34851724 Objective: To test two mouse lung organoid mechanotransductive models to address deficiencies in cell culture models. Summary: Cyclic stretch increased TGF-β and integrin-mediated signaling,

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The role of BDNF-mediated neuroplasticity in cardiovascular regulation within the hypothalamus and brainstem

Thorsdottir DJ (2021) The role of BDNF-mediated neuroplasticity in cardiovascular regulation within the hypothalamus and brainstem. Univ Vermont, Dept Pharmacology 1387Thesis. Summary: This PhD dissertation to determine the mechanism behind BDNF-mediated cardiovascular regulation. Usage: Rats received bilateral NTS injections of vehicle or Anti-DBH-SAP, which selectively lesions catecholaminergic neurons. Treatment increased blood pressure in the GFP

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Oxytocin-conjugated saporin injected into the substantia nigra of male rats alters the activity of the nigrostriatal dopaminergic system: A behavioral and neurochemical study

Sanna F, Bratzu J, Angioni L, Pina Sorighe M, Cocco C, Argiolas A, Melis MR (2021) Oxytocin-conjugated saporin injected into the substantia nigra of male rats alters the activity of the nigrostriatal dopaminergic system: A behavioral and neurochemical study. Brain Res 1773:147705. doi: 10.1016/j.brainres.2021.147705 PMID: 34744015 Objective: To investigate the effects of Oxytocin-SAP in the

Oxytocin-conjugated saporin injected into the substantia nigra of male rats alters the activity of the nigrostriatal dopaminergic system: A behavioral and neurochemical study Read More »

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