de Almeida AS, Bernardes LB, Trevisan G (2021) TRP channels in cancer pain. Eur J Pharmacol 904:174185. doi: 10.1016/j.ejphar.2021.174185 PMID: 34015320 Objective: To describe the role of TRP vanilloid 1 (TRPV1) and TRP ankyrin 1 (TRPA1) involved in cancer pain mechanisms. Summary: Several studies have revealed that the administration of TRPV1 or TRPA1 agonists/antagonists and […]
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Whalley K (2021) Sneezing pathway revealed. Nat Rev Neurosci 22(8):455. doi: 10.1038/s41583-021-00491-3 See: Li F et al. Sneezing reflex is mediated by a peptidergic pathway from nose to brainstem. Cell 184(14):3762-3773.e10, 2021. Related Products: NMB-SAP (Cat. #IT-70)
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Meng H, Du Z, Lu W, Wang Q, Sun X, Jiang Y, Wang Y, Li C, Tu P (2021) Baoyuan decoction (BYD) attenuates cardiac hypertrophy through ANKRD1-ERK/GATA4 pathway in heart failure after acute myocardial infarction. Phytomedicine 89:153617. doi: 10.1016/j.phymed.2021.153617 PMID: 34157504 Objective: To explore whether BYD plays a protective role against heart failure (HF) by
Cano G, Hernan SL, Sved AF (2021) Centrally projecting edinger-westphal nucleus in the control of sympathetic outflow and energy homeostasis. Brain Sci 11(8):1005. doi: 10.3390/brainsci11081005 Objective: To test the hypothesis that Edinger-Westphal nucleus (EWcp) integrates multimodal signals (stress, thermal, metabolic, endocrine, etc.) and modulates the sympathetic output simultaneously to multiple effector organs to maintain energy
Cui YH, Zhou SF, Liu Y, Wang S, Li F, Dai RP, Hu ZL, Li CQ (2021) Injection of anti-proBDNF attenuates hippocampal-dependent learning and memory dysfunction in mice with sepsis-associated encephalopathy. Front Neurosci 15:665757. doi: 10.3389/fnins.2021.665757 PMID: 34354558 Objective: To study the effects and associated mechanism of hippocampal proBDNF in a lipopolysaccharide (LPS)-induced sepsis-associated encephalopathy
McMahon D, O’Reilly MA, Hynynen K (2021) Therapeutic agent delivery across the blood-brain barrier using focused ultrasound. Annu Rev Biomed Eng 23:89-113. doi: 10.1146/annurev-bioeng-062117-121238 PMID: 33752471 Summary: Review of the use of focused ultrasound, in combination with circulating microbubbles, can be used to transiently and noninvasively increase cerebrovascular permeability with a high level of spatial
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Kiyokawa H, Yamaoka A, Matsuoka C, Tokuhara T, Abe T, Morimoto M (2021) Airway basal stem cells reutilize the embryonic proliferation regulator, Tgfβ-Id2 axis, for tissue regeneration. Dev Cell 56(13):1917-1929.e9. doi: 10.1016/j.devcel.2021.05.016 PMID: 34129836 Objective: To investigate the molecular mechanisms regulating how basal cells contribute to adult tissue regeneration by shifting from slow cycling to
Li F, Jiang H, Shen X, Yang W, Guo C, Wang Z, Xiao M, Cui L, Luo W, Kim BS, Chen Z, Huang AJW, Liu Q (2021) Sneezing reflex is mediated by a peptidergic pathway from nose to brainstem. Cell 184(14):3762-3773.e10. doi: 10.1016/j.cell.2021.05.017 Objective: To test the hypothesis that a neuronal population postsynaptic to nasal
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Takeuchi Y, Nagy AJ, Barcsai L, Li Q, Ohsawa M, Mizuseki K, Berényi A (2021) The medial septum as a potential target for treating brain disorders associated with oscillopathies. Front Neural Circuits 15:701080. doi: 10.3389/fncir.2021.701080 Summary: The medial septum (MS) may be a potential target for treating neurological and psychiatric disorders with abnormal oscillations (oscillopathies)
Li Y, Bao Y, Zheng H, Qin Y, Hua B (2021) Can Src protein tyrosine kinase inhibitors be combined with opioid analgesics? Src and opioid-induced tolerance, hyperalgesia and addiction. Biomed Pharmacother 139:111653. doi: 10.1016/j.biopha.2021.111653 Summary: In this review the authors discuss the important role Src protein tyrosine kinase plays in the adverse consequences of clinical