Author name: Kristen Hartman

RIPpore: A novel host-derived method for the identification of ricin intoxication through oxford nanopore direct RNA sequencing

Ryan Y, Harrison A, Trivett H, Hartley C, David J, Clark GC, Hiscox JA (2022) RIPpore: A novel host-derived method for the identification of ricin intoxication through oxford nanopore direct RNA sequencing. Toxins (Basel) 14(7):470. doi: 10.3390/toxins14070470 PMID: 35878208 Objective: The Depurination event could be detected using Oxford Nanopore Technologies (ONT) direct RNA sequencing, detecting […]

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Antibody-based preparative regimens for cell, tissue and organ transplantation

Van Hentenryck M, Li Z, Murphy PM, Czechowicz A (2022) Antibody-based preparative regimens for cell, tissue and organ transplantation. (eds. 162). OBM Transplantation 6(3):162. doi: 10.21926/obm.transplant.2203162 Objective: Provide a review of progress in the use of antibodies to support cell and tissue transplantation with a particular focus on induction of donor-specific tolerance for solid organ

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Synchronous intracellular delivery of EGFR-targeted antibody-drug conjugates by p38-mediated non-canonical endocytosis

Takahashi JI, Nakamura S, Onuma I, Zhou Y, Yokoyama S, Sakurai H (2022) Synchronous intracellular delivery of EGFR-targeted antibody-drug conjugates by p38-mediated non-canonical endocytosis. Sci Rep 12(1):11561. doi: 10.1038/s41598-022-15838-8 PMID: 35798841 Objective: The binding of cetuximab to EGFR suppresses ligand-induced signaling events. The authors demonstrate that synchronous non-canonical EGFR endocytosis can increase the efficacy of

Synchronous intracellular delivery of EGFR-targeted antibody-drug conjugates by p38-mediated non-canonical endocytosis Read More »

Neuropeptide Toxins

Q: What are neuropeptide-toxins and how do they work? A: Neuropeptide-toxin conjugates are made up of the ribosome-inactivating protein, saporin, coupled to a naturally-occurring or synthetically-modified neuropeptide such as Substance P or dermorphin. The conjugate has binding specificity similar to the native, unconjugated neuropeptide. When the neuropeptide binds to its cognate receptor, the conjugate is

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Sensory and motor visual functions in Parkinson’s Disease with respect to freezing of gait symptoms

Alhassan M (2022) Sensory and motor visual functions in Parkinson’s Disease with respect to freezing of gait symptoms. J Ophthalmol & Vis Sci 7(2):1069. Objective: This review article summarizes the results from previous studies focusing on visual functions in Parkinson’s Disease patients. Summary: Freezing of gait (FOG) is considered to be a motor disorder symptom

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Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection

Gao X, Zhang S, Gou J, Wen Y, Fan L, Zhou J, Zhou G, Xu G, Zhang Z (2022) Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection. J Infect 85(4):418-427. doi: 10.1016/j.jinf.2022.06.030 PMID: 35793758 Objective: To determine the role of angiotensin converting enzyme 2 (ACE2) as the receptor for SARS-CoV-2 entry, is

Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection Read More »

Design and synthesis of glycosylated cholera toxin b subunit as a tracer of glycoprotein trafficking in organelles of living cells

Maki Y, Kawata K, Liu Y, Goo KY, Okamoto R, Kajihara Y, Satoh A (2022) Design and synthesis of glycosylated cholera toxin b subunit as a tracer of glycoprotein trafficking in organelles of living cells. Chemistry 28(37):e202201253. doi: 10.1002/chem.202201253 PMID: 35604098 Related Products: Cholera Toxin B, Recombinant (Cat. #PR-14)

Design and synthesis of glycosylated cholera toxin b subunit as a tracer of glycoprotein trafficking in organelles of living cells Read More »

Behavioral plasticity: Role of neuropeptides in shaping feeding responses

Levine AS, Jewett DC, Kotz CM, Olszewski PK (2022) Behavioral plasticity: Role of neuropeptides in shaping feeding responses. Appetite 174:106031. doi: 10.1016/j.appet.2022.106031 PMID: 35395362 Objective: Review studies on feeding behavior involving neuropeptides that influence behavioral plasticity – primarily opioids, orexin, neuropeptide Y, and oxytocin. Summary: Eating behavior is influenced by a number of external factors,

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A strength endurance exercise paradigm mitigates deficits in hypoglossal-tongue axis function, strength, and structure in a rodent model of hypoglossal motor neuron degeneration

Murphy ER, Thompson R, Osman KL, Haxton C, Brothers M, Lee L, Warncke K, Smith CL, Keilholz AN, Hamad A, Golzy M, Bunyak F, Ma L, Nichols NL, Lever TE (2022) A strength endurance exercise paradigm mitigates deficits in hypoglossal-tongue axis function, strength, and structure in a rodent model of hypoglossal motor neuron degeneration. Front

A strength endurance exercise paradigm mitigates deficits in hypoglossal-tongue axis function, strength, and structure in a rodent model of hypoglossal motor neuron degeneration Read More »

Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome

Li S, Li W, Yuan J, Bullova P, Wu J, Zhang X, Liu Y, Plescher M, Rodriguez J, Bedoya-Reina OC, Jannig PR, Valente-Silva P, Yu M, Henriksson MA, Zubarev RA, Smed-Sörensen A, Suzuki CK, Ruas JL, Holmberg J, Larsson C, Christofer Juhlin C, von Kriegsheim A, Cao Y, Schlisio S (2022) Impaired oxygen-sensitive regulation of

Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome Read More »

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