Author name: Kristen Hartman

Stimulation of the muscarinic receptor M4 activates quiescent neural precursor cells and ameliorates medial septum cholinergic lesion-induced impairments in adult hippocampal neurogenesis

Madrid LI, Bandhavkar S, Hafey K, Jimenez-Martin J, Milne M, Coulson EJ, Jhaveri DJ (2022) Stimulation of the muscarinic receptor M4 activates quiescent neural precursor cells and ameliorates medial septum cholinergic lesion-induced impairments in adult hippocampal neurogenesis. bioRxiv 2022.08.25.505357. doi: 10.1101/2022.08.25.505357 Objective: To investigate the contribution of basal forebrain medial septum (MS) and diagonal band […]

Stimulation of the muscarinic receptor M4 activates quiescent neural precursor cells and ameliorates medial septum cholinergic lesion-induced impairments in adult hippocampal neurogenesis Read More »

Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation

Imado E, Sun S, Abawa AR, Tahara T, Kochi T, Huynh TNB, Asano S, Hasebe S, Nakamura Y, Hisaoka-Nakashima K, Kotake Y, Irifune M, Tsuga K, Takuma K, Morioka N, Kiguchi N, Ago Y (2022) Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation. Neurochem Int 160:105415. doi: 10.1016/j.neuint.2022.105415 Objective: To further

Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation Read More »

From immunotoxins to suicide toxin delivery approaches: Is there a clinical opportunity? 

Ardini M, Vago R, Fabbrini MS, Ippoliti R (2022) From immunotoxins to suicide toxin delivery approaches: Is there a clinical opportunity?. Toxins (Basel) 14(9):579. doi: 10.3390/toxins14090579 PMID: 36136517 Objective: To give an overview describing some of the bacterial and plant enzymes studied so far for their delivery and controlled expression in tumor models. Summary: “Suicide

From immunotoxins to suicide toxin delivery approaches: Is there a clinical opportunity?  Read More »

From immunotoxins to suicide toxin delivery approaches: Is there a clinical opportunity?

Ardini M, Vago R, Fabbrini MS, Ippoliti R (2022) From immunotoxins to suicide toxin delivery approaches: Is there a clinical opportunity?. Toxins (Basel) 14(9):579. doi: 10.3390/toxins14090579 PMID: 36136517 Objective: To give an overview describing some of the bacterial and plant enzymes studied so far for their delivery and controlled expression in tumor models. Summary: “Suicide

From immunotoxins to suicide toxin delivery approaches: Is there a clinical opportunity? Read More »

Sarco(endo)plasmic reticulum Ca2+-ATPase function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice

Cleverdon REG, Braun JL, Geromella MS, Whitley KC, Marko DM, Hamstra SI, Roy BD, MacPherson REK, Fajardo VA (2022) Sarco(endo)plasmic reticulum Ca2+-ATPase function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice. iScience 25(9):104972. doi: 10.1016/j.isci.2022.104972 PMID: 36093052 Objective: To investigate whether sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) function would differ in muscles from

Sarco(endo)plasmic reticulum Ca2+-ATPase function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice Read More »

Bovine bone gelatin-derived peptides: Food processing characteristics and evaluation of antihypertensive and antihyperlipidemic activities

Cao S, Wang Z, Xing L, Zhou L, Zhang W (2022) Bovine bone gelatin-derived peptides: Food processing characteristics and evaluation of antihypertensive and antihyperlipidemic activities. J Agric Food Chem 70(32):9877-9887. doi: 10.1021/acs.jafc.2c02982 PMID: 35917452 Objective: To evaluate the food processing properties of bovine bone gelatin-derived peptides (BGPs) and their effects and mechanisms on hypertension and

Bovine bone gelatin-derived peptides: Food processing characteristics and evaluation of antihypertensive and antihyperlipidemic activities Read More »

In vivo visualization and molecular targeting of the cardiac conduction system

Goodyer WR, Beyersdorf BM, Duan L, van den Berg NS, Mantri S, Galdos FX, Puluca N, Buikema JW, Lee S, Salmi D, Robinson ER, Rogalla S, Cogan DP, Khosla C, Rosenthal EL, Wu SM (2022) In vivo visualization and molecular targeting of the cardiac conduction system. J Clin Invest e156955. doi: 10.1172/jci156955 Objective: To engineer

In vivo visualization and molecular targeting of the cardiac conduction system Read More »

Self-assembling nanocarriers from engineered proteins: Design, functionalization, and application for drug delivery

Li Y, Champion JA (2022) Self-assembling nanocarriers from engineered proteins: Design, functionalization, and application for drug delivery. Adv Drug Deliv Rev 189:114462. doi: 10.1016/j.addr.2022.114462 PMID: 35934126 Objective: Review recent advances in protein nano-carriers that are from ground-up design recombinant proteins. Summary: Nanocarriers with a size range of 10-200 nm have emerged as platforms with significant

Self-assembling nanocarriers from engineered proteins: Design, functionalization, and application for drug delivery Read More »

Cannabinoid receptors and glial response following a basal forebrain cholinergic lesion

Llorente-Ovejero A, Bengoetxea de Tena I, Martínez-Gardeazabal J, Moreno-Rodríguez M, Lombardero L, Manuel I, Rodríguez-Puertas R (2022) Cannabinoid receptors and glial response following a basal forebrain cholinergic lesion. ACS Pharmacol Transl Sci 5(9):791-802. doi: 10.1021/acsptsci.2c00069 PMID: 36110372 Objective: The endocannabinoid system is involved in the control of learning, memory, and neuroinflammatory processes and plays a

Cannabinoid receptors and glial response following a basal forebrain cholinergic lesion Read More »

Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis

Orciani C, Hall H, Pentz R, Foret MK, Do Carmo S, Cuello AC (2022) Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis. J Neurochem 163(2):149-167. doi: 10.1111/jnc.15683 PMID: 35921478 Objective: To determine whether reciprocal interaction of basal forebrain cholinergic neurons (BFCN) impact neurotrophin

Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis Read More »

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