Author name: Kristen Hartman

The role of GABA-ergic interneurons in CA1 and dentate gyrus for sequence learning

Weeden CS, Morris AM, Rossi CA, Roberts JM, Kesner RP (2010) The role of GABA-ergic interneurons in CA1 and dentate gyrus for sequence learning. Neuroscience 2010 Abstracts 99.26/KKK12. Society for Neuroscience, San Diego, CA. Summary: The hippocampus (HPP) plays an important role in temporal and spatial memory. Lesion investigations of the CA1 region of HPP […]

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Cholinergic innervation of the hippocampus is not neccesary for episodic memory, but is required for context-place learning in rats

Easton A, Phil D, Fitchett A, Eacott MJ, Baxter MG (2010) Cholinergic innervation of the hippocampus is not neccesary for episodic memory, but is required for context-place learning in rats. Neuroscience 2010 Abstracts 99.27/KKK13. Society for Neuroscience, San Diego, CA. Summary: Loss of cholinergic cortical input is associated with diseases in which episodic memory impairment

Cholinergic innervation of the hippocampus is not neccesary for episodic memory, but is required for context-place learning in rats Read More »

Neurotrophin/receptor expression in urinary bladder of mice with overexpression of NGF in urothelium.

Girard BM, Malley SE, Vizzard MA (2011) Neurotrophin/receptor expression in urinary bladder of mice with overexpression of NGF in urothelium. Am J Physiol Renal Physiol 300(2):F345-55. doi: 10.1152/ajprenal.00515.2010 PMID: 21048026 Summary: Chronic overexpression of nerve growth factor (NGF) in the urinary bladder results in neuronal sprouting, increased voiding frequency, and referred somatic hypersensitivity. The authors

Neurotrophin/receptor expression in urinary bladder of mice with overexpression of NGF in urothelium. Read More »

Developmental origin of preBotzinger Complex respiratory neurons.

Gray PA, Hayes JA, Ling GY, Llona I, Tupal S, Picardo MCD, Ross SE, Hirata T, Corbin JG, Eugenin J, Del Negro CA (2010) Developmental origin of preBotzinger Complex respiratory neurons. J Neurosci 30(44):14883-14895. doi: 10.1523/JNEUROSCI.4031-10.2010 PMID: 21048147 Summary: Breathing in adult rats requires a subset of neurons in the preBötzinger Complex (preBötC) that express

Developmental origin of preBotzinger Complex respiratory neurons. Read More »

Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment.

Gompf HS, Mathai C, Fuller PM, Wood DA, Pedersen NP, Saper CB, Lu J (2010) Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment. J Neurosci 30(43):14543-14551. doi: 10.1523/JNEUROSCI.3037-10.2010 Objective: To examine arousal due to environmental stimuli after lesioning of the Locus ceruleus (LC). Summary: Lesioned animals did not show sustained neurobehavioral

Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment. Read More »

Spatial memory alterations by activation of septal 5HT(1A) receptors: no implication of cholinergic septohippocampal neurons.

Koenig J, Lecourtier L, Cosquer B, Pereira PM, Cassel J (2011) Spatial memory alterations by activation of septal 5HT(1A) receptors: no implication of cholinergic septohippocampal neurons. Psychopharmacology (Berl) 214(2):437-454. doi: 10.1007/s00213-010-2049-7 Summary: These experiments examined what effect damaged cholinergic neurons would have on memory deficits induced by the 5-HT1A/5-HT7 receptor agonist 8-OH-DPAT. Rats received 0.4

Spatial memory alterations by activation of septal 5HT(1A) receptors: no implication of cholinergic septohippocampal neurons. Read More »

Targeting Tools: GAT1-SAP

News Tools /

GAT-1 is a sodium-coupled neurotransmitter transporter responsible for moving g-aminobutyric acid (GABA) across cell membranes. GABA is the predominant inhibitory neurotransmitter in the mammalian central nervous system. GAT-1 is widely distributed in both the central and peripheral nervous systems. GAT-1 and GABA are present in numerous neuronal pathways, some of which are implicated in epilepsy,

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Immunotoxin Tracers

Q: In a previous question, you mentioned mixing anti-DBH-SAP (Cat. #IT-03) with a tracer to monitor drug delivery. Which tracer would you recommend? We were thinking of using FluoroGold. If we do not use a tracer, we were thinking of using a neutral red solution to dilute the stock of anti-DBH-SAP in order to be

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Featured Article: Targeted ablation of sympathetic neurons reduces ventricular arrhythmias and autonomic dysreflexia

Lujan HL, DiCarlo SE (2010) Featured Article: Targeted ablation of sympathetic neurons reduces ventricular arrhythmias and autonomic dysreflexia. Targeting Trends 11(4) Related Products: CTB-SAP (Cat. #IT-14) Read the featured article in Targeting Trends. See Also: Lujan HL et al. Targeted Ablation of Cardiac Sympathetic Neurons Reduces the Susceptibility to Ischemia-Induced Sustained Ventricular Tachycardia in Conscious

Featured Article: Targeted ablation of sympathetic neurons reduces ventricular arrhythmias and autonomic dysreflexia Read More »

$3 Million Award from National Cancer Institute

SP SAP Drug Development /

Advanced Targeting Systems, the company that pioneered the targeting of specific cell types to manipulate them for the treatment of diseases and for research into the function of biological systems, has been awarded $3 million from the National Cancer Institute (NCI). Representatives from the NCI stated that the Advanced Targeting Systems proposal was ranked #1

$3 Million Award from National Cancer Institute Read More »

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