Author name: Kristen Hartman

Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis

Orciani C, Hall H, Pentz R, Foret MK, Do Carmo S, Cuello AC (2022) Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis. J Neurochem 163(2):149-167. doi: 10.1111/jnc.15683 PMID: 35921478 Objective: To determine whether reciprocal interaction of basal forebrain cholinergic neurons (BFCN) impact neurotrophin […]

Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis Read More »

Stimulation of Akt phosphorylation and glucose transport by metalloporphyrins with peroxynitrite decomposition catalytic activity

Eccardt AM, Pelzel RJ, Bell TP, Fisher JS (2022) Stimulation of Akt phosphorylation and glucose transport by metalloporphyrins with peroxynitrite decomposition catalytic activity. Catalysts 12(8):849. doi: 10.3390/catal12080849 PMID: 37123089 Objective: To determine whether a catalytic action of iron porphyrin compounds would be related to their stimulation of insulin signaling and glucose uptake in C2C12 myotubes.

Stimulation of Akt phosphorylation and glucose transport by metalloporphyrins with peroxynitrite decomposition catalytic activity Read More »

Perinatal correlated retinal activity is required for the wiring of visual axons in non-image forming nuclei

Negueruela S, Morenilla C, Herrera M, Coca Y, Florez-Paz D, López-Cascales MT, Gomis A, Herrera E (2022) Perinatal correlated retinal activity is required for the wiring of visual axons in non-image forming nuclei. bioRxiv 2022.07.27.501692. doi: 10.1101/2022.07.27.501692 Related Products: Melanopsin Rabbit Polyclonal (Cat. #AB-N38)

Perinatal correlated retinal activity is required for the wiring of visual axons in non-image forming nuclei Read More »

Differential role of GABAergic and cholinergic ventral pallidal neurons in behavioral despair, conditioned fear memory and active coping.

Akmese C, Sevinc C, Halim S, Unal G (2022) Differential role of GABAergic and cholinergic ventral pallidal neurons in behavioral despair, conditioned fear memory and active coping. bioRxiv 2022.07.21.500949. doi: 10.1101/2022.07.21.500949 Related Products: 192-IgG-SAP (Cat. #IT-01), GAT1-SAP (Cat. #IT-32)

Differential role of GABAergic and cholinergic ventral pallidal neurons in behavioral despair, conditioned fear memory and active coping. Read More »

Saporin toxin delivered by engineered colloidal nanoparticles is strongly effective against cancer cells

Salvioni L, Testa F, Barbieri L, Giustra M, Bertolini JA, Tomaino G, Tortora P, Prosperi D, Colombo M (2022) Saporin toxin delivered by engineered colloidal nanoparticles is strongly effective against cancer cells. Pharmaceutics 14(7):1517. doi: 10.3390/pharmaceutics14071517 PMID: 35890411 Objective: Using Saporin-containing iron oxide nanoparticles to selectively eliminate cancer cells. Summary: Saporin [PR-01] is trapped inside

Saporin toxin delivered by engineered colloidal nanoparticles is strongly effective against cancer cells Read More »

A century searching for the neurons necessary for wakefulness

Grady FS, Boes AD, Geerling JC (2022) A century searching for the neurons necessary for wakefulness. Front Neurosci 16:930514. doi: 10.3389/fnins.2022.930514 Objective: This review article attempts to summarize research that has investigated the neurons necessary for wakefulness. Summary: The authors summarize animal experiments and research performed in different brain regions to further understand wakefulness. Several

A century searching for the neurons necessary for wakefulness Read More »

RIPpore: A novel host-derived method for the identification of ricin intoxication through oxford nanopore direct RNA sequencing

Ryan Y, Harrison A, Trivett H, Hartley C, David J, Clark GC, Hiscox JA (2022) RIPpore: A novel host-derived method for the identification of ricin intoxication through oxford nanopore direct RNA sequencing. Toxins (Basel) 14(7):470. doi: 10.3390/toxins14070470 PMID: 35878208 Objective: The Depurination event could be detected using Oxford Nanopore Technologies (ONT) direct RNA sequencing, detecting

RIPpore: A novel host-derived method for the identification of ricin intoxication through oxford nanopore direct RNA sequencing Read More »

Antibody-based preparative regimens for cell, tissue and organ transplantation

Van Hentenryck M, Li Z, Murphy PM, Czechowicz A (2022) Antibody-based preparative regimens for cell, tissue and organ transplantation. (eds. 162). OBM Transplantation 6(3):162. doi: 10.21926/obm.transplant.2203162 Objective: Provide a review of progress in the use of antibodies to support cell and tissue transplantation with a particular focus on induction of donor-specific tolerance for solid organ

Antibody-based preparative regimens for cell, tissue and organ transplantation Read More »

Synchronous intracellular delivery of EGFR-targeted antibody-drug conjugates by p38-mediated non-canonical endocytosis

Takahashi JI, Nakamura S, Onuma I, Zhou Y, Yokoyama S, Sakurai H (2022) Synchronous intracellular delivery of EGFR-targeted antibody-drug conjugates by p38-mediated non-canonical endocytosis. Sci Rep 12(1):11561. doi: 10.1038/s41598-022-15838-8 PMID: 35798841 Objective: The binding of cetuximab to EGFR suppresses ligand-induced signaling events. The authors demonstrate that synchronous non-canonical EGFR endocytosis can increase the efficacy of

Synchronous intracellular delivery of EGFR-targeted antibody-drug conjugates by p38-mediated non-canonical endocytosis Read More »

Neuropeptide Toxins

Q: What are neuropeptide-toxins and how do they work? A: Neuropeptide-toxin conjugates are made up of the ribosome-inactivating protein, saporin, coupled to a naturally-occurring or synthetically-modified neuropeptide such as Substance P or dermorphin. The conjugate has binding specificity similar to the native, unconjugated neuropeptide. When the neuropeptide binds to its cognate receptor, the conjugate is

Neuropeptide Toxins Read More »

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