Author name: Kristen Hartman

Expression pattern of brain-derived neurotrophic factor and its associated receptors: Implications for exogenous neurotrophin application

Schulze J, Staecker H, Wedekind D, Lenarz T, Warnecke A (2022) Expression pattern of brain-derived neurotrophic factor and its associated receptors: Implications for exogenous neurotrophin application. Hear Res 413:108098. doi: 10.1016/j.heares.2020.108098 PMID: 33143996 Objective: To investigate the mechanisms of brain-derived neurotrophic factor (BDNF) in the inner ear, by analyzing the expression of mature BDNF (mBDNF), […]

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Nonsteroidal anti-inflammatory drug (ketoprofen) delivery differentially impacts phrenic long-term facilitation in rats with motor neuron death induced by intrapleural CTB-SAP injections

Borkowski LF, Keilholz AN, Smith CL, Canda KA, Nichols NL (2021) Nonsteroidal anti-inflammatory drug (ketoprofen) delivery differentially impacts phrenic long-term facilitation in rats with motor neuron death induced by intrapleural CTB-SAP injections. Exp Neurol 347:113892. doi: 10.1016/j.expneurol.2021.113892 Objective: To determine the effect of ketoprofen delivery on enhanced phrenic long-term facilitation (pLTF) Summary: pLTF was surprisingly

Nonsteroidal anti-inflammatory drug (ketoprofen) delivery differentially impacts phrenic long-term facilitation in rats with motor neuron death induced by intrapleural CTB-SAP injections Read More »

Mouse lung organoid responses to reduced, increased, and cyclic stretch

Joshi R, Batie MR, Fan Q, Varisco BM (2022) Mouse lung organoid responses to reduced, increased, and cyclic stretch. Am J Physiol Lung Cell Mol Physiol 322(1):L162-L173. doi: 10.1152/ajplung.00310.2020 PMID: 34851724 Objective: To test two mouse lung organoid mechanotransductive models to address deficiencies in cell culture models. Summary: Cyclic stretch increased TGF-β and integrin-mediated signaling,

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The role of BDNF-mediated neuroplasticity in cardiovascular regulation within the hypothalamus and brainstem

Thorsdottir DJ (2021) The role of BDNF-mediated neuroplasticity in cardiovascular regulation within the hypothalamus and brainstem. Univ Vermont, Dept Pharmacology 1387Thesis. Summary: This PhD dissertation to determine the mechanism behind BDNF-mediated cardiovascular regulation. Usage: Rats received bilateral NTS injections of vehicle or Anti-DBH-SAP, which selectively lesions catecholaminergic neurons. Treatment increased blood pressure in the GFP

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Oxytocin-conjugated saporin injected into the substantia nigra of male rats alters the activity of the nigrostriatal dopaminergic system: A behavioral and neurochemical study

Sanna F, Bratzu J, Angioni L, Pina Sorighe M, Cocco C, Argiolas A, Melis MR (2021) Oxytocin-conjugated saporin injected into the substantia nigra of male rats alters the activity of the nigrostriatal dopaminergic system: A behavioral and neurochemical study. Brain Res 1773:147705. doi: 10.1016/j.brainres.2021.147705 PMID: 34744015 Objective: To investigate the effects of Oxytocin-SAP in the

Oxytocin-conjugated saporin injected into the substantia nigra of male rats alters the activity of the nigrostriatal dopaminergic system: A behavioral and neurochemical study Read More »

Antibody-drug conjugates plus Janus kinase inhibitors enable MHC-mismatched allogeneic hematopoietic stem cell transplantation

Persaud SP, Ritchey JK, Kim S, Lim S, Ruminski PG, Cooper ML, Rettig MP, Choi J, DiPersio JF (2021) Antibody-drug conjugates plus Janus kinase inhibitors enable MHC-mismatched allogeneic hematopoietic stem cell transplantation. J Clin Invest 131(24):e145501. doi: 10.1172/JCI145501 Objective: To demonstrate that biotinylated anti-CD45-SAP or anti-cKit-SAP mixed with Streptavidin-Saporin along with Janus kinase 1/2, enables

Antibody-drug conjugates plus Janus kinase inhibitors enable MHC-mismatched allogeneic hematopoietic stem cell transplantation Read More »

Basal forebrain cholinergic neurons selectively drive coordinated motor learning in mice

Li Y, Hollis E (2021) Basal forebrain cholinergic neurons selectively drive coordinated motor learning in mice. J Neurosci 41(49):10148-10160. doi: 10.1523/JNEUROSCI.1152-21.2021 PMID: 34750228 Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP), mu p75-SAP (Cat. #IT-16)

Basal forebrain cholinergic neurons selectively drive coordinated motor learning in mice Read More »

Converting extracellular vesicles into nanomedicine: loading and unloading of cargo

Joshi BS, Ortiz D, Zuhorn IS (2021) Converting extracellular vesicles into nanomedicine: loading and unloading of cargo. Materials Today Nano 16:100148. doi: 10.1016/j.mtnano.2021.100148 Objective: To provide a comprehensive overview of (i) methods for the loading of EVs with therapeutic cargo, (ii) methods for EV surface functionalization to direct EVs to target cells, and (iii) methods

Converting extracellular vesicles into nanomedicine: loading and unloading of cargo Read More »

Perspective: Estrogen and the risk of cognitive decline: a missing choline(rgic) link?

Bortz J, Klatt KC, Wallace TC (2021) Perspective: Estrogen and the risk of cognitive decline: a missing choline(rgic) link?. Adv Nutr 13(2):376-387. doi: 10.1093/advances/nmab145 Objective: Explore the relationship between cognitive aging and sex hormones, the cholinergic system, and choline as an essential nutrient. Summary: This perspective identifies numerous areas for future preclinical and clinical research,

Perspective: Estrogen and the risk of cognitive decline: a missing choline(rgic) link? Read More »

The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development

Kunimura K, Fukui Y (2021) The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development. Int Immunol 33(12):731-736. doi: 10.1093/intimm/dxab065 Objective: To investigate the molecular mechanisms of how IL-31 is produced in helper T cells upon stimulation and transmits the itch sensation to the brain. Summary: This review highlights recent

The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development Read More »

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