Author name: Kristen Hartman

Macrophage migration inhibitory factor mediates peripheral nerve injury-induced hypersensitivity by curbing dopaminergic descending inhibition.

Wang X, Ma S, Wu H, Shen X, Xu S, Guo X, Bolick ML, Wu S, Wang F (2018) Macrophage migration inhibitory factor mediates peripheral nerve injury-induced hypersensitivity by curbing dopaminergic descending inhibition. Exp Mol Med 50(2):e445. doi: 10.1038/emm.2017.271 Objective: To investigate whether the proinflammatory cytokine MIF participates in the regulation of neuropathic hypersensitivity by […]

Macrophage migration inhibitory factor mediates peripheral nerve injury-induced hypersensitivity by curbing dopaminergic descending inhibition. Read More »

Toxins as tools: Fingerprinting neuronal pharmacology.

Israel MR, Morgan M, Tay B, Deuis JR (2018) Toxins as tools: Fingerprinting neuronal pharmacology. Neurosci Lett 679:4-14. doi: 10.1016/j.neulet.2018.02.001 Summary: This review article provides an overview of the experimental techniques used to assess the effects that toxins have on neuronal function, as well as discussion on toxins that have been used as tools, with

Toxins as tools: Fingerprinting neuronal pharmacology. Read More »

Strategies to overcome 5-FU resistance in cancer

Targeting Topics /

Congratulations to the Selbo laboratory for their recent publication using Anti-CD105-SAP. This targeted toxin was previously part of the BETA program. As first to publish using this product, Selbo’s group receives a $500 product credit and applause for their great work. 5-Fu Resistant Emt-Like Pancreatic Cancer Cells Are Hypersensitive to Photochemical Internalization of the Novel

Strategies to overcome 5-FU resistance in cancer Read More »

S-Glutathionylation of p47phox sustains superoxide generation in activated neutrophils

Nagarkoti S, Dubey M, Awasthi D, Kumar V, Chandra T, Kumar S, Dikshit M (2018) S-Glutathionylation of p47phox sustains superoxide generation in activated neutrophils. Biochim Biophys Acta Mol Cell Res 1865(2):444-454. doi: 10.1016/j.bbamcr.2017.11.014 PMID: 29195919 Objective: To investigate the role of S-Glutathionylation of p47phox. Summary: In Phorbol 12-myristate 13-acetate (PMA) or Nitric oxide (NO) treated

S-Glutathionylation of p47phox sustains superoxide generation in activated neutrophils Read More »

Fentanyl induces rapid onset hyperalgesic priming: Type I at peripheral and type II at central nociceptor terminals.

Araldi D, Khomula EV, Ferrari LF, Levine JD (2018) Fentanyl induces rapid onset hyperalgesic priming: Type I at peripheral and type II at central nociceptor terminals. J Neurosci 38(9):2226-2245. doi: 10.1523/JNEUROSCI.3476-17.2018 Objective: To evaluate priming, at both nociceptor terminals, the effect of local administration of agents that reverse type I (protein translation) or type II

Fentanyl induces rapid onset hyperalgesic priming: Type I at peripheral and type II at central nociceptor terminals. Read More »

Synergistic cytotoxic effect on gastric cancer cells of an immunotoxin cocktail in which antibodies recognize different epitopes on CDH17

Kusano-Arai O, Iwanari H, Kudo S, Kikuchi C, Yui A, Akiba H, Matsusaka K, Kaneda A, Fukayama M, Tsumoto K, Hamakubo T (2018) Synergistic cytotoxic effect on gastric cancer cells of an immunotoxin cocktail in which antibodies recognize different epitopes on CDH17. Monoclon Antib Immunodiagn Immunother 37:1-11. doi: 10.1089/mab.2017.0043 Objective: To determine if an immunotoxin

Synergistic cytotoxic effect on gastric cancer cells of an immunotoxin cocktail in which antibodies recognize different epitopes on CDH17 Read More »

Characterization of the first fully human anti-TEM1 scFv in models of solid tumor imaging and immunotoxin-based therapy.

Yuan X, Yang M, Chen X, Zhang X, Sukhadia S, Musolino N, Bao H, Chen T, Xu C, Wang Q, Santoro S, Ricklin D, Hu J, Lin R, Yang W, Li Z, Qin W, Zhao A, Scholler N, Coukos G (2018) Characterization of the first fully human anti-TEM1 scFv in models of solid tumor imaging

Characterization of the first fully human anti-TEM1 scFv in models of solid tumor imaging and immunotoxin-based therapy. Read More »

The transient intermediate plexiform layer, a plexiform layer-like structure temporarily existing in the inner nuclear layer in developing rat retina

Park HW, Kim H-L, Park YS, Kim I-B (2018) The transient intermediate plexiform layer, a plexiform layer-like structure temporarily existing in the inner nuclear layer in developing rat retina. Exp Neurobiol 27:28-33. doi: 10.5607/en.2018.27.1.28 Related Products: SSP-SAP (Cat. #IT-11)

The transient intermediate plexiform layer, a plexiform layer-like structure temporarily existing in the inner nuclear layer in developing rat retina Read More »

Catecholaminergic projections into an interconnected forebrain network control the sensitivity of male rats to diet-induced obesity

Lee SJ, Jokiaho AJ, Sanchez-Watts G, Watts AG (2018) Catecholaminergic projections into an interconnected forebrain network control the sensitivity of male rats to diet-induced obesity. Am J Physiol Regul Integr Comp Physiol 314(6):R811-R823. doi: 10.1152/ajpregu.00423.2017 Objective: To investigate the role of hindbrain catecholamine neuron pathways and their contribution to long-term energy homeostasis by controlling obesogenic

Catecholaminergic projections into an interconnected forebrain network control the sensitivity of male rats to diet-induced obesity Read More »

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