Nagarkoti S, Dubey M, Awasthi D, Kumar V, Chandra T, Kumar S, Dikshit M (2018) S-Glutathionylation of p47phox sustains superoxide generation in activated neutrophils. Biochim Biophys Acta Mol Cell Res 1865(2):444-454. doi: 10.1016/j.bbamcr.2017.11.014
Objective: To investigate the role of S-Glutathionylation of p47phox.
Summary: In Phorbol 12-myristate 13-acetate (PMA) or Nitric oxide (NO) treated neutrophils a subunit of NOX2, p47phox gets glutathionylated to sustain ROS generation along with a decrease in catalase, Grx-1 activity and change in GSH/GSSG ratio.
Usage: Western blot
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