Targeting Trends Newsletter 12q4

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page.


Newsletter Highlights

  • Spring Brain Conference, March 20-23, 2013 (page 2)
  • SfN 2012 Poster Schedule (page 5)
  • Teaser Winners (page 5)
  • mu p75-SAP (page 7)
  • Complete and Submit the Targeting Teaser online!

Partial basal forebrain cholinergic depletion leaves working memory susceptible to the effects of systemic inflammation – read article (continued on page 6)

Contributed by Dr. Colm Cunningham, Trinity College, Institute of Neuroscience & School of Biochemistry and Immunology, Dublin, Ireland Product information related to cover article: mu p75-SAP (Cat. #IT-16)

24th Annual Spring Brain Conference – Register NOW to Attend

Upcoming Events

  • Society for Neurosciences (SFN) / October 13-17, 2012 / New Orleans, LA / Booth #824
  • American Society for Cell Biology (ASCB) / December 15-19, 2012 / San Francisco, CA / Booth #1138
  • Spring Brain Conference (SBC) / March 20-23, 2013 / Sedona, AZ
  • American Association for Cancer Research (AACR) / April 4-10, 2013 / Washington DC

Recent Scientific References (read online)

  • Brown RE, Basheer R, McKenna JT, Strecker RE, McCarley RW. (2012) Control of sleep and wakefulness. Physiol Rev 92(3):1087-1187. (Cat. #IT-01, Cat. # IT-03, Cat. # IT-20)
  • Mishra SK, Holzman S, Hoon MA. (2012) A nociceptive signaling role for neuromedin B. J Neurosci 32(25):8686-8695. (Cat. #IT-11,Cat. # IT-40,Cat. # IT-21)
  • Paolone G, Lee TM, Sarter M. (2012) Time to pay attention: attentional performance time-stamped prefrontal cholinergic activation, diurnality, and performance. J Neurosci 32(35):12115-12128. (Cat. #IT-01)
  • Parent M, Bedard MA, Aliaga A, Soucy JP, Landry St-Pierre E, Cyr M, Kostikov A, Schirrmacher E, Massarweh G, Rosa-Neto P. (2012) PET imaging of cholinergic deficits in rats using [(18)F]fluoroethoxybenzovesamicol ([(18)F]FEOBV). Neuroimage 62(1):555-561. (Cat. #IT-01)
  • Koppen JR, Winter SS, Stuebing SL, Cheatwood JL, Wallace DG. (2012) Infusion of GAT1-saporin into the medial septum/vertical limb of the diagonal band disrupts self-movement cue processing and spares mnemonic function. Brain Struct Funct Epub (Cat. #IT-32)
  • Gil-Bea FJ, Gerenu G, Aisa B, Kirazov LP, Schliebs R, Ramirez MJ. (2012) Cholinergic denervation exacerbates amyloid pathology and induces hippocampal atrophy in Tg2576 mice. Neurobiol Dis 48(3):439-446. (Cat. #IT-16)
  • Ma J, Tai SK, Leung LS. (2012) Septohippocampal GABAergic neurons mediate the altered behaviors induced by n-methyl-D-aspartate receptor antagonists. Hippocampus Epub (Cat. #IT-20)
  • Easton A, Fitchett AE, Eacott MJ, Baxter MG. (2011) Medial septal cholinergic neurons are necessary for context-place memory but not episodic-like memory. Hippocampus 21(9):1021-1027. (Cat. #IT-01)
  • Daubert DL, McCowan M, Erdos B, Scheuer DA. (2012) Nucleus of the Solitary Tract catecholaminergic neurons modulate the cardiovascular response to psychological stress in rats. J Physiol 590(Pt 19):4881-4895. (Cat. #IT-03)
  • Lowrance S, Matchynski J, Rossignol J, Dekorver N, Sandstrom M, Dunbar G. (2012) CXB-909 Attenuates Cognitive Deficits in the Mu-P-75 Saporin Mouse Model of Alzheimer’s Disease. Neuroscience & Medicine 3(1):65-68. (Cat. #IT-16)
  • Laplante F, Zhang ZW, Huppe-Gourgues F, Dufresne MM, Vaucher E, Sullivan RM. (2012) Cholinergic depletion in nucleus accumbens impairs mesocortical dopamine activation and cognitive function in rats. Neuropharmacology 63(6):1075-1084. (Cat. #IT-42, Cat. #IT-35)
  • Pedrino GR, Freiria-Oliveira AH, Almeida Colombari DS, Rosa DA, Cravo SL. (2012) A2 noradrenergic lesions prevent renal sympathoinhibition induced by hypernatremia in rats. PLoS One 7(5):e37587. (Cat. #IT-03, Cat. #PR-01)
  • Huang TY, Lin LS, Cho KC, Chen SJ, Kuo YM, Yu L, Wu FS, Chuang JI, Chen HI, Jen CJ. (2012) Chronic treadmill exercise in rats delicately alters the Purkinje cell structure to improve motor performance and toxin resistance in the cerebellum. J Appl Physiol 113(6):889-895. (Cat. #IT-02)
  • Lacerda CM, Kisiday J, Johnson B, Orton EC. (2012) Local serotonin mediates cyclic strain-induced phenotype transformation, matrix degradation, and glycosaminoglycan synthesis in cultured sheep mitral valves. Am J Physiol Heart Circ Physiol 302(10):H1983-90. (Cat. #AB-N09)
  • Man SH, Geranton SM, Hunt SP. (2012) Lamina I NK1 expressing projection neurones are functional in early postnatal rats and contribute to the setting up of adult mechanical sensory thresholds. Mol Pain 8(1):35. (Cat. #IT-07, Cat. #IT-21)
  • Li AJ, Wiater MF, Oostrom MT, Smith BR, Wang Q, Dinh TT, Roberts BL, Jansen HT, Ritter S. (2012) Leptin-sensitive neurons in the arcuate nuclei contribute to endogenous feeding rhythms. Am J Physiol Regul Integr Comp Physiol 302(11):R1313-26. (Cat. #IT-47, Cat. #IT-21)
  • Ovsepian SV, Dolly JO, Zaborszky L. (2012) Intrinsic voltage dynamics govern the diversity of spontaneous firing profiles in basal forebrain noncholinergic neurons. J Neurophysiol 108(2):406-418. (Cat. #FL-01)
  • Kaminski KL, Watts AG. (2012) Intact Catecholamine Inputs to the Forebrain Are Required for Appropriate Regulation of CRH and Vasopressin Gene Expression by Corticosterone in the Rat Paraventricular Nucleus. J Neuroendocrinol Epub (Cat. #IT-03, Cat. # IT-18)
  • Kruger HS, Hanganu-Opatz IL. (2013) Neonatal cholinergic lesion alters the acoustic structure of infant rat vocalization but not the early cognitive development. Dev Psychobiol 55(3):294-308. (Cat. #IT-01)

Targeting Talk: SfN Product Abstracts (see listing)

Partial basal forebrain cholinergic depletion leaves working memory susceptible to the effects of systemic inflammation- read article (continued from page 1)

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