09q3

Targeting Trends 2009 Newsletter

Read the 2009 Newsletters 2009, issue 1: Selective deletion of CD8+ T cells by saporin-coupled MHC class I tetramers / by Hess PR, Buntzman AS, Murray SL, Young EF, Frelinger JA / featuring Streptavidin-ZAP (Cat. #IT-27), FITC-labeled SAP antibody (Cat. #FL-02) SFN Poster of the Year Targeting Talk: IgM Primary Antibody Assay 2009, issue 2: Deletion of Catecholaminergic Neurons …

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Targeting Topics 09q3

Photostimulation of retrotrapezoid nucleus phox2b-expressing neurons in vivo produces long-lasting activation of breathing in rats Abbott SB, Stornetta RL, Fortuna MG, Depuy SD, West GH, Harris TE, Guyenet PG J Neurosci 29(18):5806-5819, 2009. The retrotrapezoid nucleus (RTN) contains a subpopulation of cells that are thought to function as central respiratory chemoreceptors. The authors used bilateral …

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Targeting Article: SBIR Grant Funded: Selective Activation in Neuronal Populations

ATS has been awarded a Phase I SBIR grant to develop a new line of products. Dr. Douglas Lappi is the Principal Investigator and Brian Russell is the Lead Scientist on the project. Molecules targeted towards cell surface markers have been used for years to identify specific cell types. It has been demonstrated over the …

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Cover Article: Depletion of Microglia by Mac-1-SAP in Mouse Hippocampal Slice Cultures Enhances Ischemia-Like Neurodegeneration

Contributed by Maria Montero (a), Berta Gonzalez (b), Jens Zimmer (a)(a) Anatomy and Neurobiology, University of Southern Denmark, Denmark(b) Histology Unit, Autonomous University of Barcelona, Spain Microglial cells contribute about 12% of the cells in the brain, acting as “biosensors” for homeostatic regulation in normal and pathological conditions.[3,13] Resting microglial cells in the adult brain …

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