2008, issue 1: Role of medial septal GABAergic neurons in learning and extinction: Effects of the novel GABA immunotoxin GAT1-SAP / by Pang KCH, Jiao X, Servatius RJ / featuring GAT1-SAP (Cat. #IT-32) SFN Poster of the Year Targeting Talk: Secondary Conjugates & Reducing Agents Targeting Tools: New Products Stimulate Instead of Eliminate (SP-CTA [Substance …
Do targeted toxin-treated cells die by apoptosis? There are, allegedly, two ways for cells to die: by apoptosis or necrosis. According to Fiorenzo Stirpe (the discoverer of saporin), saporin-intoxicated cells die both ways, some by one, others by the other. There is a good literature that states that cells die by apoptosis, for instance: Bergamaschi …
Noradrenergic innervation of the dorsal medial prefrontal cortex modulates hypothalamo-pituitary-adrenal responses to acute emotional stress. Radley JJ, Williams B, Sawchenko PE J Neurosci 28:5806-5816, 2008. Rats were injected with 90-120 nl of 0.475-µg/µl anti-DBH-SAP (Cat. #IT-03) into the cortical field containing noradrenergic neurons that project to the dorsal medial prefrontal cortex. The results indicate that …
Contributed by Jason J. Radley, Ph.D., Laboratory of Neuronal Structure and FunctionThe Salk Institute for Biological Studies and Foundation for Medical Research, La Jolla, CA 92037, USA The medial prefrontal cortex (mPFC) has been proposed to play a role in the inhibition of hypothalamo-pituitary-adrenal (HPA) responses to emotional stress via influences on neuroendocrine effector mechanisms …