The Angiotensin II type 1 receptor (AT-1R) is the primary effector of Angiotensin II, a key regulator of blood pressure and fluid homeostasis. It is involved in pathogenesis of several cardiovascular diseases such as hypertension, cardiac hypertrophy and congestive heart failure. Angiotensin II interacts with two types of G-protein coupled membrane receptors, AT-1R (type 1) and AT-2R (type 2). AT-1 has three isoforms in rat: AT-1A (359 aa), AT-1B (359 aa), and AT-1C (177 aa). Rat AT-1R’s are predicted to contain seven transmembrane domains. The N-terminus is predicted to be extracellular, while the C-terminus is predicted to be cytoplasmic. AT-1R’s are expressed in the liver, kidney, aorta, lung, uterus, ovary, spleen, heart, adrenal and vascular smooth muscle.
This peptide corresponds to a cytoplasmic region of the receptor.
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