MOA-SAP [IT-92, KIT-92]

a tool for eliminating cells that express specific galactose residues; targeted via MOA, eliminated via saporin

SKU: IT-92 Category: Quantity: Individual 25 ug, Individual 100 ug, Individual 250 ug, Individual 1 mg, Kit w/controls 25 ug, Kit w/controls 100 ug, Kit w/controls 250 ug | Host: e. coli | Conjugate: streptavidin-saporin | Usage: eliminates cells |

The blood group B lectin present in the mushroom Marasmius oreades is highly specific for Galα1,3Gal and also recognizes the porcine xenotransplantation epitope Galα1,3Galß1,4GlcNAc/Glc and the blood group B determinant. Marasmium oreades agglutinin (MOA) is specific towards these epitopes present on chain ends of glycoproteins (e.g. porcine tissues and organs, bovine thyroglobulin, 3T3 cells, murine laminin, Ehrlich ascites tumor cells) and glycolipids. In vivo studies have shown glomerular microvascular endothelial binding of this lectin, thus this conjugate could be used as an effective tool for studying glomerular endothelial injury, acute kidney failure, and thrombotic microangiopathies.

MOA-SAP is a bonded conjugate between the blood group B lectin present in the mushroom Marasmius Oreades and the secondary conjugate Streptavidin-ZAP containing the ribosome-inactivating protein, saporin. It specifically eliminates cells expressing Galα1,3Gal and Galα1,3Galß1,4GlcNAc/Glc.

MOA-SAP is available individually (Cat. #IT-92) or as a kit (Cat. #KIT-92) which includes MOA-SAP and Blank-Streptavidin-SAP (Cat. #IT-27B)

MOA Products:

MOA-SAP (Cat. #IT-92)

MOA (Cat. #PR-29)

Recombinant Biotinylated MOA (Cat. #PR-29bt)

keywords: Lectin, Marasmium oreades, agglutinin, mushroom, MOA, Galα1,3Gal, Galα1,3Galß1,4GlcNAc/Glc, carbohydrate, sugar, blood group B, thrombotic microangiopathies, glomerular endothelial injury, glycoproteins, 3T3 cells, saporin, streptavidin, brain, neuroscience


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