Anti-CD126 is a monoclonal antibody that specifically binds to CD126 (80kDa), which is the alpha chain of the interleukin-6 receptor (IL-6R). CD126, a member of the immunoglobulin superfamily is found on various cells, such as T cells, Plasma cells, monocytes, hepatocytes, activated B cells, granulocytes, epithelial cells, and fibroblasts. IL-6 signaling through CD126 plays a role in immune responses, and in some cases, it contributes to disease processes like autoimmune diseases and certain cancers.
Anti-CD126-SAP is a chemical conjugate of mouse anti human antibody to CD126 and the ribosome-inactivating protein, saporin.
Anti-CD126-SAP specifically eliminates cells that express the IL-6R. All other cells are left untouched.
The following control is included for validating the specificity of the beta conjugate: BIgG-SAP Mouse (Cat. #IT-74)
This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.
*Data subject to review by the scientific team at ATS. See complete details here.
keywords: Saporin, CD126, IL-6R, interleukin-6 receptor, T cells, plasma cells, IL-6 signaling, autoimmune