CD11b is an alpha subunit of Mac-1, also known as CR3. Mac-1-SAP targets rat species using a monoclonal antibody targeting CR3 complement (C3bi) receptor expressed on macrophages, granulocytes, monocytes, NK cells, and dendritic cells. This antibody can recognize a shared common epitope between CD11b and CD11c. CD11b/c are involved in bacterial phagocytosis and are components of integrins, important for adhesion of neutrophils to surfaces. Mac-1-SAP is a potential tool for removing contaminating macrophages from primary cultures to determine their role(s) in autoimmune diseases and in degenerative disease such as Alzheimer’s.
Mac-1-SAP is a bonded toxin between a biotinylated rat monoclonal antibody to CD11b/c and the secondary conjugate Streptavidin-ZAP containing the ribosome-inactivating protein, saporin.
Mac-1-SAP rat eliminates cells expressing rat CD11b/c. All other cells are left untouched.
The following control is included for validating the specificity of the beta conjugate: BIgG-SAP Mouse (Cat. #IT-74)
This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.
*Data subject to review by the scientific team at ATS. See complete details here.
keywords: Saporin, Mac-1, CD11b, CD11b/c, C3bi receptor, microglia, macrophages, CR3, alzheimer’s disease, AD