alpha Melanocyte stimulating hormone (αMSH) is a peptide produced in the intermediate lobe of the pituitary gland. While αMSH stimulates the production and release of melanin by skin melanocytes, it also plays roles in appetite, energy homeostasis, inflammation, analgesia, and sexual arousal signals in the brain. αMSH binds melanocortin receptors 1, 3, 4, and 5; the lowest dissociation constant is with MC1R. It does not bind MC2R. These receptors are expressed in a number of places including cutaneous melanocytes, leukocytes, adrenal cortex, central nervous system, and peripheral tissues. αMSH-SAP can be used to study skin cancer, food intake, and exocrine disorders, and other systems.
αMSH-SAP eliminates cells expressing melanocortin receptors.
The following control is included for validating the specificity of the beta conjugate: Blank-Streptavidin-SAP (Cat. #IT-27B).
This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.
*Data subject to review by the scientific team at ATS. See complete details here.