Adrenocorticotropic hormone (also known as corticotrophin) is a peptide hormone secreted by the anterior pituitary gland. It is a stress-related hormone that promotes the production and release of cortisol, as well as playing a role in circadian rhythm. In the brain, ACTH receptors are found primarily on adrenocortical cells in the adrenal cortex. Receptors are also expressed in osteoblasts. The ACTH-SAP conjugate will eliminate cells expressing the ACTH receptor. This conjugate can be used to study acute multiple sclerosis, rheumatoid arthritis, allergic conjunctivitis, and ulcerative colitis, among other conditions.
ACTH-SAP eliminates cells expressing the ACTH receptor.
BIgG-SAP rabbit (Cat. #IT-75) is included as a control.
This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.
*Data subject to review by the scientific team at ATS. See complete details here.