SKU: BETA-021 Category: Conjugate: streptavidin-saporin | Usage: eliminates cells |

Adrenocorticotropic hormone (also known as corticotrophin) is a peptide hormone secreted by the anterior pituitary gland.  It is a stress-related hormone that promotes the production and release of cortisol, as well as playing a role in circadian rhythm.  In the brain, ACTH receptors are found primarily on adrenocortical cells in the adrenal cortex.  Receptors are also expressed in osteoblasts. The ACTH-SAP conjugate will eliminate cells expressing the ACTH receptor.  This conjugate can be used to study acute multiple sclerosis, rheumatoid arthritis, allergic conjunctivitis, and ulcerative colitis, among other conditions.

ACTH-SAP eliminates cells expressing the ACTH receptor.

The following control is recommended for validating the specificity of the beta conjugate: BIgG-SAP rabbit (Cat. #IT-75).

This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.

*Data subject to review by the scientific team at ATS. See complete details here.