During neuronal development, neurotrophic factors have a pivotal role in the organization of the nervous system by selecting which neurons will survive and terminally differentiate. These effects are mediated by specific neurotrophin receptors. Tyrosine kinase A, known as trkA (the high-affinity NGF receptor) is responsible for the retrograde transport of NGF, neuron survival and gene regulation of the chronic forebrain neurons, and is required for normal development of the peripheral nervous system as well as the function of central forebrain neurons.
This antibody recognizes rat trkA (high affinity nerve growth factor receptor). Histochemical antisera to trkA was developed in rabbit using the extracellular fragment from rat trkA (amino acids 1-416); this product has been purified by protein A column chromatography. The antibody is routinely tested by western blot.
Applications include immunohistochemistry, immunoprecipitation, and immunoblotting.
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