During neuronal development, neurotrophic factors have a pivotal role in the organization of the nervous system by selecting which neurons will survive and terminally differentiate. These effects are mediated by specific neurotrophin receptors. Tyrosine kinase A, known as trkA (the high-affinity NGF receptor) is responsible for the retrograde transport of NGF, neuron survival and gene regulation of the chronic forebrain neurons, and is required for normal development of the peripheral nervous system as well as the function of central forebrain neurons.
This antibody recognizes rat trkA (high affinity nerve growth factor receptor). Histochemical antisera to trkA was developed in rabbit using the extracellular fragment from rat trkA (amino acids 1-416); this product has been purified by protein A column chromatography. The antibody is routinely tested by western blot.
Applications include immunohistochemistry, immunoprecipitation, and immunoblotting.
keywords: high affinity nerve growth factor receptor, NGFr, NGF receptor, Tyrosine kinase A, trkA, Anti-trkA, Anti-Tyrosine kinase A, brain, neuroscience
KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia
Zhang C, Shen L, Zhu Y, Xu R, Deng Z, Liu X, Ding Y, Wang C, Shi Y, Bei L, Wei D, Thorne RF, Zhang XD, Yu L, Chen S (2021) KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia. Theranostics 11(6):2691-2705. doi: 10.7150/thno.50571 PMID: 33456567
Objective: To identify histone lysine demethylases (KDMs) with altered expression in chronic myelogenous leukemia (CML) and define their contribution to imatinib resistance.
Summary: KDM6A promotes imatinib-resistance in CML cells. The identification of the KDM6A/YY1/TRKA axis as a novel imatinib-resistance mechanism represents an unexplored avenue to overcome tyrosine kinase inhibitor resistance in CML.
Usage: Western blot
Related Products: trkA Rabbit Polyclonal (Cat. #AB-N03)
The reduced level of growth factors in an animal model of depression is accompanied by regulated necrosis in the frontal cortex but not in the hippocampus
Kucharczyk M, Kurek A, Pomierny B, Detka J, Papp M, Tota K, Budziszewska B (2018) The reduced level of growth factors in an animal model of depression is accompanied by regulated necrosis in the frontal cortex but not in the hippocampus. Psychoneuroendocrinology 94:121-133. doi: 10.1016/j.psyneuen.2018.05.008 PMID: 29775875
Objective: To investigate if the different types of stress alter neuronal plasticity markers distinctively in the frontal cortex (FCx) and in the hippocampus (Hp).
Summary: The authors concluded that chronic stress during pregnancy can result in serious alterations in the functioning of the FCx of the progeny, facilitating the development of depressive behavior later in life. They also suggest that the altered energy metabolism may redirect pro-NGF/p75NTR/ATF2 signaling in the cortical neurons towards cellular death resembling regulated necrosis, rather than apoptosis.
Usage: Western blot (1:1000)
Related Products: trkA Rabbit Polyclonal (Cat. #AB-N03)
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