Cholera Toxin subunit A Rabbit Polyclonal [AB-43]

$333.00

SKU: AB-43 Category: Quantity: 100 ul | Antibody Type: Polyclonal | Host: rabbit | Conjugate: unconjugated | Usage: ELISA, immunoblotting |

Cholera Toxin (CT) is produced by a Gram negative bacteria, Vibrio cholera, and is a member of the AB toxin family. The holotoxin consists of a single A subunit (CTA) that has a molecular weight of 27 kDA and five surrounding B subunits (CTB). After the cell internalizes CT, CTA activates the cAMP pathway by ribosylating adenylate cyclase. The effect of CTA on adenylate cyclase provides a useful tool for studying signal transduction mechanisms. This antibody is used to bind to CTA.

This antibody recognizes the catalytic A subunit of cholera toxin (CTA). Recombinant CTA was used as the immunogen. It is routinely tested by ELISA.

Applications include ELISA and immunoblotting.

keywords: cholera toxin subunit A, CT, CTA, CTB, catalytic A subunit, Anti-CTA, Anti-Cholera Toxin subunit A

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A therapeutic chemical chaperone inhibits cholera intoxication and unfolding/translocation of the cholera toxin A1 subunit

Taylor M, Banerjee T, Navarro-Garcia F, Huerta J, Massey S, Burlingame M, Pande AH, Tatulian SA, Teter K (2011) A therapeutic chemical chaperone inhibits cholera intoxication and unfolding/translocation of the cholera toxin A1 subunit. PLoS One 6(4):e18825. doi: 10.1371/journal.pone.0018825 PMID: 21526142

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Cholera toxin up-regulates endoplasmic reticulum proteins that correlate with sensitivity to the toxin

Dixit G, Mikoryak C, Hayslett T, Bhat A, Draper RK (2008) Cholera toxin up-regulates endoplasmic reticulum proteins that correlate with sensitivity to the toxin. Exp Biol Med (Maywood) 233(2):163-175. doi: 10.3181/0705-RM-132 PMID: 18222971

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Cholera Toxin subunit A Rabbit Polyclonal (Cat. #AB-43)

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