Search Results for: IT-27

Saporin toxin-conjugated monoclonal antibody targeting prostate-specific membrane antigen has potent anticancer activity.

Kuroda K, Liu H, Kim S, Guo M, Navarro V, Bander NH (2010) Saporin toxin-conjugated monoclonal antibody targeting prostate-specific membrane antigen has potent anticancer activity. Prostate 70(12):1286-1294. doi: 10.1002/pros.21164 Summary: Current treatments for prostate cancer are only moderately effective. In this work the authors examined the cytotoxic efficacy of an anti-prostate-specific membrane antigen (PMSA) antibody […]

Saporin toxin-conjugated monoclonal antibody targeting prostate-specific membrane antigen has potent anticancer activity. Read More »

Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity.

Stratford EW, Bostad M, Castro R, Skarpen E, Berg K, Hogset A, Myklebost O, Selbo PK (2013) Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity. Biochim Biophys Acta 1830(8):4235-4243. doi: 10.1016/j.bbagen.2013.04.033 Summary: In this work the authors used photochemical internalization (PCI) to facilitate local cytosolic toxin release from

Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity. Read More »

Photochemical internalization (PCI): a technology for drug delivery.

Berg K, Weyergang A, Prasmickaite L, Bonsted A, Hogset A, Strand MT, Wagner E, Selbo PK (2010) Photochemical internalization (PCI): a technology for drug delivery. (eds. Gomer C). In: Photodynamic Therapy. Methods in Molecular Biology. 635:133-145. Humana Press, Totowa, NJ. doi: 10.1007/978-1-60761-697-9_10 Summary: This review discusses photochemical internalization (PCI), which is a method used to

Photochemical internalization (PCI): a technology for drug delivery. Read More »

The novel EpCAM-targeting monoclonal antibody 3-17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines.

Lund K, Bostad M, Skarpen E, Braunagel M, Krauss S, Duncan A, Hogset A, Selbo P (2014) The novel EpCAM-targeting monoclonal antibody 3-17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines. MAbs 6(4):1038-1050. doi: 10.4161/mabs.28207 Summary: The epithelial cell adhesion molecule (EpCAM) is an attractive diagnostic

The novel EpCAM-targeting monoclonal antibody 3-17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines. Read More »

T-cell reconstitution without T-cell immunopathology in two models of T-cell-mediated tissue destruction.

Penaloza-MacMaster P, Masopust D, Ahmed R (2009) T-cell reconstitution without T-cell immunopathology in two models of T-cell-mediated tissue destruction. Immunology 128:164-171. doi: 10.1111/j.1365-2567.2009.03080.x Summary: Although antigen-specific T cells are vital to adaptive immune responses, they also contribute to a variety of diseases. In this work the authors examined the possibility of selectively removing epitope-specific T

T-cell reconstitution without T-cell immunopathology in two models of T-cell-mediated tissue destruction. Read More »

Immunology

Targeting Topics /

NGFr (ME20.4, p75) Mouse Monoclonal (Cat. #AB-N07) The p75 neurotrophin receptor (p75NTR), also known as the low affinity nerve growth factor receptor, binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NTR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective

Immunology Read More »

Collagen-like cell-penetrating peptides

Yamazaki CM, Nakase I, Endo H, Kishimoto S, Mashiyama Y, Masuda R, Futaki S, Koide T (2013) Collagen-like cell-penetrating peptides. Angew Chem Int Ed Engl 52(21):5497-5500. doi: 10.1002/anie.201301266 Objective: To overcome drawbacks of cell-penetrating peptide (CPP)-conjugated forms, namely instability against attack by proteases, and binding to serum proteins that lowers the availability of the CPP

Collagen-like cell-penetrating peptides Read More »

High-content analysis of antibody phage-display library selection outputs identifies tumor selective macropinocytosis-dependent rapidly internalizing antibodies.

Ha K, Bidlingmaier S, Zhang Y, Su Y, Liu B (2014) High-content analysis of antibody phage-display library selection outputs identifies tumor selective macropinocytosis-dependent rapidly internalizing antibodies. Mol Cell Proteomics 13:3320-3331. doi: 10.1074/mcp.M114.039768 Summary: Macropinocytosis, the internalization of large endocytic vesicles called macropinosomes, is upregulated in Ras-transformed cancers. To date, large-scale antibody generation strategies have not

High-content analysis of antibody phage-display library selection outputs identifies tumor selective macropinocytosis-dependent rapidly internalizing antibodies. Read More »

Guanidinylated-Neomycin delivers large, bioactive cargo into cells through a heparan sulfate dependent pathway.

Elson-Schwab L, Garner OB, Schuksz M, Esko JD, Tor Y (2007) Guanidinylated-Neomycin delivers large, bioactive cargo into cells through a heparan sulfate dependent pathway. J Biol Chem 282(18):13585-13591. doi: 10.1074/jbc.M700463200 Summary: The uptake of high molecular weight drugs into cells is a stumbling block for some potential therapeutics. Using a neomycin derivative in which guanidinium

Guanidinylated-Neomycin delivers large, bioactive cargo into cells through a heparan sulfate dependent pathway. Read More »

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