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2019 Targeting Trends Review
Disruption of medial septum and diagonal bands of Broca cholinergic projections to the ventral hippocampus disrupt auditory fear memory.
Staib JM, Della Valle R, Knox DK (2018) Disruption of medial septum and diagonal bands of Broca cholinergic projections to the ventral hippocampus disrupt auditory fear memory. Learn Mem 152:71-79. doi: 10.1016/j.nlm.2018.05.009
Objective: To determine which efferent projections are critical for contextual fear memory discrimination and extinction memory.
Summary: The results of this study suggest that MS/vDBB cholinergic neurons are critical for fear and extinction memory.
Usage: 192-IgG saporin was infused into all brain regions at a concentration of 0.2 μg/μL dissolved in 0.2 M PBS. The total volume of each injection was 0.5 μL. Sham surgeries were accomplished using the same volume (0.5 μL) of PBS.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Targeting prostate cancer: Prostate-specific membrane antigen based diagnosis and therapy.
Wüstemann T, Haberkorn U, Babich J, Mier W (2019) Targeting prostate cancer: Prostate-specific membrane antigen based diagnosis and therapy. Med Res Rev 39(1):40-69. doi: 10.1002/med.21508 PMID: 29771460
Summary: Conjugation to the antibody was achieved by reacting the biotinylated humanized antibody to prostate-specific membrane antigen (PMSA) with Streptavidin-ZAP. Binding potency of the conjugate was comparable to that of the naked antibody and in vivo experiments proved potent for selective tumor growth inhibition in mice bearing LNCaP tumors.
Related Products: Streptavidin-ZAP (Cat. #IT-27)
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