tt2006

Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons.

McKay LC, Janczewski WA, Feldman JL (2005) Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons. Nat Neurosci 8(9):1142-1144. doi: 10.1038/nn1517

Summary: Sleep-disordered breathing is common in elderly humans as well as patients with neurodegenerative disease. The authors investigated the role of preBötzinger complex neurons of rats in respiratory rhythm generation. Using the fact that preBötzinger complex neurons in the ventrolateral medulla express the neurokinin-1 receptor, animals were given bilateral injections of SP-SAP (Cat. #IT-07). Beginning 7 days post-injection, lesioned animals displayed marked respiratory disturbances during both sleep and wakeful periods.

Related Products: SP-SAP (Cat. #IT-07)