targeted-toxins

Attila M, Salvadori S, Balboni G, Bryant SD, Lazarus LH (1993) Synthesis and receptor binding analysis of dermorphin hepta-, hexa- and pentapeptides. Int J Pept Prot Res 42:550-559. doi: 10.1111/j.1399-3011.1993.tb00363.x

Related Products: Dermorphin-SAP / MOR-SAP (Cat. #IT-12)

David T, Tassin J, Lappi DA, Baird A, Courtois Y (1992) Biphasic effect of the mitotoxin bFGF-saporin on bovine lens epithelial cell growth: effect of cell density and extracellular matrix. J Cell Physiol 153:483-490. doi: 10.1002/jcp.1041530307

Related Products: FGF-SAP (Cat. #IT-38)

Nilsson OG, Leanza G, Rosenblad C, Lappi DA, Wiley RG, Bjorklund A (1992) Spatial learning impairments in rats with selective immunolesion of the forebrain cholinergic system. NeuroReports 3:1005-1008. doi: 10.1097/00001756-199211000-00015 PMID: 1482757

Objective: To study the impact of depletion of NGF receptor-positive neurons.

Summary: 192-IgG-SAP (Cat. IT-01) is a neurotoxin that targets specific cholinergic neurons in the rat brain. When injected, it leads to severe and long-lasting impairment in spatial learning. This is associated with a significant reduction in choline acetyltransferase activity (ChAT) in the hippocampus and cortex, while other cholinergic neuron systems remain largely unaffected.

Usage: 4.7 micrograms of 192-IgG-SAP, in 7 microliters, injected into the right lateral ventricle of rats.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Book AA, Wiley RG, Schweitzer JB (1992) Specificity of 192 IgG-saporin for NGF receptor-positive cholinergic basal forebrain neurons in the rat. Brain Res 590:350-355. doi: 10.1016/0006-8993(92)91121-t

Related Products: 192-IgG-SAP (Cat. #IT-01)

Lewis EJ, Asnani LP (1992) Soluble and membrane-bound forms of dopamine b-hydroxylase are encoded by the same mRNA. J Biol Chem 267:494-500. doi: 10.1016/S0021-9258(18)48522-5

Related Products: Anti-DBH-SAP (Cat. #IT-03)

Beitz JG, Davol P, Clark JW, Kato J, Medina M, Frackelton AR Jr, Lappi DA, Baird A, Calabresi P (1992) Antitumor activity of basic fibroblast growth factor-saporin mitotoxin in vitro and in vivo. Cancer Res 52:227-230. PMID: 1309225

Related Products: FGF-SAP (Cat. #IT-38)

Gonzalez AM, Lappi DA, Buscaglia ML, Carman LS, Gage FH, Baird A (1991) Basic FGF-SAP mitotoxin in the hippocampus. Specific lethal effect on cells expressing the basic FGF receptor. Ann N Y Acad Sci 638:442-444. doi: 10.1111/j.1749-6632.1991.tb49064.x

Related Products: FGF-SAP (Cat. #IT-38)

Wiley RG, Oeltmann TN, Lappi DA (1991) Immunolesioning: Selective destruction of neurons using immunotoxin to rat NGF receptor. Brain Res 562:149-153. doi: 10.1016/0006-8993(91)91199-b

Related Products: 192-IgG-SAP (Cat. #IT-01)

Lindner V, Lappi DA, Baird A, Majack RA, Reidy MA (1991) Role of basic fibroblast growth factor in vascular lesion formation. Circ Res 68:106-113. doi: 10.1161/01.res.68.1.106

Related Products: FGF-SAP (Cat. #IT-38)

Beattie GM, Lappi DA, Baird A, Hayek A (1990) Selective elimination of fibroblasts from pancreatic islet monolayers by basic fibroblast growth factor-saporin mitotoxin. Diabetes 39:1002-1005. doi: 10.2337/diab.39.8.1002

Related Products: FGF-SAP (Cat. #IT-38)