Nilsson OG, Leanza G, Rosenblad C, Lappi DA, Wiley RG, Bjorklund A (1992) Spatial learning impairments in rats with selective immunolesion of the forebrain cholinergic system. NeuroReports 3:1005-1008. doi: 10.1097/00001756-199211000-00015 PMID: 1482757
Objective: To study the impact of depletion of NGF receptor-positive neurons.
Summary: 192-IgG-SAP (Cat. IT-01) is a neurotoxin that targets specific cholinergic neurons in the rat brain. When injected, it leads to severe and long-lasting impairment in spatial learning. This is associated with a significant reduction in choline acetyltransferase activity (ChAT) in the hippocampus and cortex, while other cholinergic neuron systems remain largely unaffected.
Usage: 4.7 micrograms of 192-IgG-SAP, in 7 microliters, injected into the right lateral ventricle of rats.
Related Products: 192-IgG-SAP (Cat. #IT-01)