targeted-toxins

Giulian D, Yu J, Li X, Tom D, Li J, Wendt E, Lin S-N, Schwarcz R, Noonan C (1996) Study of receptor-mediated neurotoxins released by HIV-1-infected, mononuclear phagocytes found in human brain. J Neurosci 16:3139-3153. doi: 10.1523/JNEUROSCI.16-10-03139.1996

Related Products: Acetylated LDL-SAP (Cat. #IT-08)

Mavroudis DA, Jiang YZ, Hensel N, Lewalle P, Couriel D, Kreitman RJ, Pastan I, Barrett AJ (1996) Specific depletion of alloreactivity against haplotype mismatched related individuals by a recombinant immunotoxin: a new approach to graft-versus-host disease prophylaxis in haploidentical bone marrow transplantation. Bone Marrow Transplant 17:793-799. PMID: 8733700

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Bannon AW, Curzon P, Gunther KL, Decker MW (1996) Effects of intraseptal injection of 192-IgG-saporin in mature and aged Long-Evans rats. Brain Res 718:25-36. doi: 10.1016/0006-8993(95)01568-x

Related Products: 192-IgG-SAP (Cat. #IT-01)

Waite JJ, Thal LJ (1996) Lesions of the cholinergic nuclei in the rat basal forebrain: excitotoxins vs. an immunotoxin. Life Sci 58:1947-1953. doi: 10.1016/0024-3205(96)00184-1

Related Products: 192-IgG-SAP (Cat. #IT-01)

Trickle K, Dornan W (1996) The “combined” 192 IGG saporin lesion approach as an anima model of alzheimer’s disease. Illinois Wesleyan Univ Thesis.

Objective: Provide evidence that injections of 192-IgG-SAP both in the medial septal area and the nucleus basalis magnocellularis creates a reliable animal model of Alzheimer’s disease (AD).

Summary: 192-IgG-SAP (IT-01) is a selective cholinergic neurotoxin. Intraventricular injections of 192-IgG-SAP into the lateral ventricles induced a 80-90% reduction of acetylcholine levels in the cortex and hippocampus. Although studies have reported an impairment of spatial learning following treatment by 192-IgG-SAP, the effects observed may be due to loss of cerebellar Purkinje cells following intraventricular injection (i.c.v.). Authors propose that through a combined medial septum and nucleus basalis magnocellularis lesioning technique, a model for AD can be created in a rat that better reflects only damage to strictly cholinergic cells in the impacted regions of the brain.

Usage: Animals received three injections of 192-IgG-SAP into the medial septal area and two (bilateral) injections into the nucleus basalis magnocellularis.

Related Products: 192-IgG-SAP (Cat. #IT-01)

McGaughy J, Kaiser T, Sarter M (1996) Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density. Behav Neurosci 110:247-265. doi: 10.1037//0735-7044.110.2.247 PMID: 8731052

Usage: Rats were administered 0.5 ul of 192-IgG-SAP (0.21 ug/0.5 ul) bilaterally within the basal forebrain.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Wiley RG (1996) Targeting toxins to neural antigens and receptors. Semin Cancer Biol 7(2):71-77. doi: 10.1006/scbi.1996.0011 PMID: 8740562

Jouvenceau A, Billard JM, Lamour Y, Dutar P (1996) Persistence of CA1 hippocampal LTP after selective cholinergic denervation. NeuroReport 7(4):948-952. doi: 10.1097/00001756-199603220-00024

Related Products: 192-IgG-SAP (Cat. #IT-01)

Kapas L, Obal Jr, F, Book AA, Schweitzer JB, Wiley RG, Krueger JM (1996) The effects of immunolesions of nerve growth factor-receptive neurons by 192 IgG-saporin on sleep. Brain Res 712:53-59. doi: 10.1016/0006-8993(95)01431-4

Related Products: 192-IgG-SAP (Cat. #IT-01)

Vnek N, Kromer LF, Wiley RG, Rothblat LA (1996) The basal forebrain cholinergic system and object memory in the rat. Brain Res 710:265-270. doi: 10.1016/0006-8993(95)01477-2

Related Products: 192-IgG-SAP (Cat. #IT-01)