targeted-toxins

Pang KCH, Nocera R (1999) Interactions between 192-IgG Saporin and intraseptal cholinergic and GABAergic drugs: role of cholinergic medial septal neurons in spatial working memory. Behav Neurosci 113:265-275. doi: 10.1037//0735-7044.113.2.265

Related Products: 192-IgG-SAP (Cat. #IT-01)

Ridley RM, Barefoot HC, MacLean CJ, Pugh P, Baker HF (1999) Different effects on learning ability after injection of the cholinergic immunotoxin ME20.4 IgG-saporin into the diagonal band of Broca, basal nucleus of Meynert, or both in monkeys. Behav Neurosci 113:303-315. doi: 10.1037//0735-7044.113.2.303

Related Products: ME20.4-SAP (Cat. #IT-15)

Potter PE, Gaughan C, Assouline Y (1999) Lesion of septal-hippocampal neurons with 192 IgG-saporin alters function of M1 muscarinic receptors. Neuropharmacol 38:579-586. doi: 10.1016/s0028-3908(98)00207-x

Related Products: 192-IgG-SAP (Cat. #IT-01)

Baxter M, Chiba A (1999) Cognitive functions of the basal forebrain. Curr Opin Neurobiol 9:178-183. doi: 10.1016/s0959-4388(99)80024-5

Objective: To recent studies of the role of the basal forebrain cholinergic neurons in attention, memory, and cortical information processing, focusing primarily on experiments using the selective cholinergic immunolesion method.

Related Products: 192-IgG-SAP (Cat. #IT-01)

See Also:

• McGaughy J et al. Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density. Behav Neurosci 110:247-265, 1996.
• Waite JJ et al. Deficit in selective and divided attention associated with cholinergic basal forebrain immunotoxic lesion produced by 192-Saporin; motoric/sensory deficit associated with Purkinje cell immunotoxic lesion produced by OX7-Saporin. Neurobiol Learn Mem 71(3):325-352, 1999.

Rossner S, Bakinde N, Zeitschel U, Schliebs R, Bigl V (1999) Cerebrospinal fluid cholinesterases–markers for loss of cholinergic basal forebrain neurons?. Int J Dev Neurosci 16(7-8):669-673. doi: 10.1016/s0736-5748(98)00077-x

Related Products: 192-IgG-SAP (Cat. #IT-01)

Martin WJ, Gupta NK, Loo CM, Rohde DS, Basbaum AI (1999) Differential effects of neurotoxic destruction of descending noradrenergic pathways on acute and persistent nociceptive processing. Pain 80:57-65. doi: 10.1016/s0304-3959(98)00194-8

Summary: The authors used Anti-DBH-SAP to re-examine the contribution of noradrenergic pathways to nociception and to morphine analgesia. They also evaluated morphine analgesia in the formalin test and found that toxin-treated animals exhibited enhanced morphine analgesia. These results establish the utility of using this immunotoxin to selectively destroy subpopulations of noradrenergic cell groups and provide evidence that acute and persistent nociception are differentially regulated by descending noradrenergic pathways.

Usage: Intrathecal treatment with Anti-DBH-SAP attenuates formalin pain (5.0 µg/20 µl).

Related Products: Anti-DBH-SAP (Cat. #IT-03)

Waite JJ, Holschneider DP, Scremin OU (1999) Selective immunotoxin-induced cholinergic deafferentation alters blood flow distribution in the cerebral cortex. Brain Res 818:1-11. doi: 10.1016/s0006-8993(98)01174-3

Related Products: 192-IgG-SAP (Cat. #IT-01)

Llewellyn-Smith IJ, Martin CL, Arnolda LF, Minson JB (1999) Retrogradely transported CTB-saporin kills sympathetic preganglionic neurons. Neuroreport 10(2):307-312. doi: 10.1097/00001756-199902050-00019

Related Products: CTB-SAP (Cat. #IT-14)

Han JS, Holland PC, Gallagher M (1999) Disconnection of the amygdala central nucleus and substantia innominata/nucleus basalis disrupts increments in conditioned stimulus processing in rats. Behav Neurosci 113:143-151. doi: 10.1037//0735-7044.113.1.143

Related Products: 192-IgG-SAP (Cat. #IT-01)

Wiley RG (1999) Molecular murder. Trends in Neurosci 22(2):61. doi: 10.1016/s0166-2236(98)01379-4