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Enteric apelin enhances the stress-induced stimulation of colonic motor functions.
Bülbül M, Sinen O, Bayramoğlu O, Akkoyunlu G (2019) Enteric apelin enhances the stress-induced stimulation of colonic motor functions. Stress 23(2):201-212. doi: 10.1080/10253890.2019.1658739 PMID: 31441348
Usage: histology (1:100)
Related Products: Corticotropin Releasing Hormone Rabbit Polyclonal (Cat. #AB-02)
Development of intestinal scaffolds that mimic native mammalian intestinal tissue
Ladd MR, Costello CM, Gosztyla C, Werts AD, Johnson B, Fulton WB, Martin LY, Redfield EJ, Crawford B, Panaparambil R, Sodhi CP, March JC, Hackam DJ (2019) Development of intestinal scaffolds that mimic native mammalian intestinal tissue. Tissue Eng Part A 25(17-18):1225-1241. doi: 10.1089/ten.TEA.2018.0239 PMID: 30652526
Objective: To develop a scaffold for the generation of an artificial intestine that specifically mimics the architecture and biomechanical properties of the native small intestine, and to evaluate the scaffold in vitro and in vivo.
Summary: Novel scaffolds were developed using PGS with promise for use in artificial intestine for individuals with short bowel syndrome.
Usage: Histology, immunohistochemistry, microscopy (1:500)
Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01)
Metalloprotease inhibitor timp proteins control FGF-2 bioavailability and regulate skeletal growth.
Saw S, Aiken A, Fang H, McKee TD, Bregant S, Sanchez O, Chen Y, Weiss A, Dickson BC, Czarny B, Sinha A, Fosang A, Dive V, Waterhouse PD, Kislinger T, Khokha R (2019) Metalloprotease inhibitor timp proteins control FGF-2 bioavailability and regulate skeletal growth. J Cell Biol 218(9):3134-3152. doi: 10.1083/jcb.201906059 PMID: 31371388
Usage: immunostaining (1:100)
Related Products: Fibroblast Growth Factor Rabbit Polyclonal, mammalian (Cat. #AB-07)
Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration.
Małecki JM, Willemen HLDM, Pinto R, Ho AYY, Moen A, Eijkelkamp N, Falnes PØ (2019) Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration. J Biol Chem 294(31):11654-11664. doi: 10.1074/jbc.RA119.009045 PMID: 31213526
Usage: Western blot
Related Products: Tri-methyl Lysine Rabbit Polyclonal (Cat. #AB-265)
Mixed vehicle emissions induces angiotensin ii and cerebral microvascular angiotensin receptor expression in C57Bl/6 mice and promotes alterations in integrity in a blood-brain barrier coculture model.
Suwannasual U, Lucero J, Davis G, McDonald JD, Lund AK (2019) Mixed vehicle emissions induces angiotensin ii and cerebral microvascular angiotensin receptor expression in C57Bl/6 mice and promotes alterations in integrity in a blood-brain barrier coculture model. Toxicol Sci 170(2):525-535. doi: 10.1093/toxsci/kfz121 PMID: 31132127
Objective: To investigate the hypothesis that inhalation exposure to a mixture of gasoline and diesel vehicle engine emissions (MVE) results in altered central nervous system microvascular integrity mediated by Ang II-AT1 signaling.
Summary: Inhalation exposure to traffic-generated pollutants results in altered BBB integrity, mediated through Ang II-AT1 signaling and inflammation, which is exacerbated by a high-fat diet.
Usage: Antibody was used in immunofluorescent staining of cerebral tissue. Brain sections (10 mm) were prepared for AT1 receptor (1:1000).
Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)
A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours.
Fu R, Han C-F, Ni T, Di L, Liu L-J, Lv W-C, Bi Y-R, Jiang N, He Y, Li H-M, Wang S, Xie H, Chen B-A, Wang X-S, Weiss SJ, Lu T, Guo Q-L, Wu Z-Q (2019) A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours. Nat Commun 10(1):3210. doi: 10.1038/s41467-019-11278-7 PMID: 31324807
Usage: immunohistochemistry (1:100)
Related Products: Fibroblast Growth Factor Rabbit Polyclonal, mammalian (Cat. #AB-07)
∆Np63 executes an oncogenic program through the regulation of a common landscape of super-enhancer associated genes in non-small cell lung cancer
Wu SJ, Coarfa C, Abbas H, Checker R, Dhar S, Rajapakshe K, Lee MG, Flores ER (2019) ∆Np63 executes an oncogenic program through the regulation of a common landscape of super-enhancer associated genes in non-small cell lung cancer. Cell Reports 3420369. doi: 10.2139/ssrn.3420369
Objective: To investigate how ΔNp63 serves to maintain lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) through the regulation and maintenance of lung stem cells that are necessary for lung adenocarcinoma and squamous cell initiation and progression.
Summary: ∆Np63 maintains lung ADC and SCC by keeping lung stem cells in quiescence. ChIP-seq analysis of lung basal cells and alveolar type 2 (AT2) cells lacking ∆Np63 revealed a robust loss of activating histone marks at super enhancers of cell identity genes defining a unifying oncogenic role for ∆Np63 in non-small cell lung cancer.
Usage: staining
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Light responses of melanopsin-expressing ganglion cells in the foetal mammalian retina
Verweij J, Chaney SY, Bredl D, Vemaraju S, König GM, Kostenis E, Lang RA, Copenhagen DR (2019) Light responses of melanopsin-expressing ganglion cells in the foetal mammalian retina. bioRxiv 675702. doi: 10.1101/675702
Related Products: Melanopsin Rabbit Polyclonal, affinity-purified (Cat. #AB-N39)
Structural and functional defects of the respiratory neural system in the medulla and spinal cord of Pax6 mutant rats.
Ikeda K, Onimaru H, Inada H, Tien Lin S, Arata S, Osumi N (2019) Structural and functional defects of the respiratory neural system in the medulla and spinal cord of Pax6 mutant rats. Brain Res Bull 152:107-116. doi: 10.1016/j.brainresbull.2019.07.007 PMID: 31301380
Objective: To determine whether the respiratory center in the medulla functions normally in Pax6 mutant rats.
Summary: The Pax6 gene is involved in the functional development of the medullary respiratory center.
Usage: Anti-NK1r was used in immunofluorescence (1:800).
Related Products: NK-1 Receptor Rabbit Polyclonal, affinity-purified (Cat. #AB-N33AP)
MALAT1 overexpression promotes the proliferation of human periodontal ligament stem cells by upregulating fibroblast growth factor 2.
Chen P, Huang Y, Wang Y, Li S, Chu H, Rong M (2019) MALAT1 overexpression promotes the proliferation of human periodontal ligament stem cells by upregulating fibroblast growth factor 2. Exp Ther Med 18(3):1627-1632. doi: 10.3892/etm.2019.7748 PMID: 31410118
Usage: western (1:1300)
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