antibodies

Zhou Y (2019) PMP22 regulates lipid metabolism and cholesterol trafficking: The implication for hereditary peripheral neuropathies. University of Florida Thesis.

Objective: To study the extent of lipid abnormalities and to examine the underlying mechanisms, they determined the expression of lipid-related molecules, and studied morphological and functional alterations in the nerve, liver, and cultured cells from PMP22 KO mice.

Summary: The study reveals a novel role of PMP22 in regulating lipid metabolism and cholesterol trafficking, provide critical information for understanding the pathology of peripheral neuropathies, and shed light on the potential therapy for PMP22-linked neuropathies.

Related Products: NGFR (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

McNamara M (2019) Development of novel therapies for marfan syndrome using a human iPSC-disease model. University of Cambridge Thesis. doi: 10.17863/CAM.38053

Objective: To address different strategies that could potentially be developed into treatments of Marfan Syndrome (MFS) for the clinic.

Summary: Preliminary results show that their disease model exhibits reduced GSK3β protein expression despite GSK3β inhibition proving to be beneficial in restoring some of the phenotypic features. Further experimental efforts need to be effectuated to harness precisely the GSK3β-dependent signaling pathways that govern the phenotypic abnormalities and characterize their MFS disease model.

Usage: immunocytochemistry (1:500)

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Aoyagi Y, Furuyama T, Inoue K, Matsuda D, Matsubara Y, Okahara A, Ago T, Nakashima Y, Mori M, Matsumoto T (2019) Attenuation of angiotensin II–induced hypertension in BubR1 low‐expression mice via repression of angiotensin II receptor 1 overexpression. J Am Heart Assoc 8(23):e011911. doi: 10.1161/JAHA.118.011911 PMID: 31787052

Usage: western blot

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Lu W, Wang Q, Sun X, He H, Wang Q, Wu Y, Liu Y, Wang Y, Li C (2019) Qishen Granule improved cardiac remodeling via balancing M1 and M2 macrophages. Front Pharmacol 10:1399. doi: 10.3389/fphar.2019.01399 PMID: 31824322

Objective: To explore the effect of Qishen Granule (QSG) on the release of splenic monocytes, the recruitment of monocytes into heart tissues and the differentiation of macrophages under ischemic conditions.

Summary: Compounds of Chinese medicine have synergistic effects on cardiac and splenic organs through regulating differentiation of monocytes/macrophages in inhibiting myocardial remodeling.

Usage: Western blot

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

Li X (2019) Light stimulation into dorsal raphe nucleus contributes to antidepressant effect for a stressed rat model. bioRxiv 821421. doi: 10.1101/821421 PMID: 0

Usage: immunohisochemistry (1:500)

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Abd El‐Rahman SS, Fayed HM (2019) Targeting AngII/AT1R signaling pathway by perindopril inhibits ongoing liver fibrosis in rat. J Tissue Eng Regen Med 13:2131-2141. doi: 10.1002/term.2940 PMID: 31348596

Usage: IHC (1:100)

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Li J, Xiang X, Xu H, Shi Y (2019) Cilostazol promotes angiogenesis and increases cell proliferation after myocardial ischemia–reperfusion injury through a camp-dependent mechanism. Cardiovasc Eng Technol 10(4):638-647. doi: 10.1007/s13239-019-00435-0 PMID: 31625080

Usage: western

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Avrampou K, Pryce KD, Ramakrishnan A, Sakloth F, Gaspari S, Serafini RA, Mitsi V, Polizu C, Swartz C, Ligas B, Richards A, Shen L, Carr FB, Zachariou V (2019) RGS4 maintains chronic pain symptoms in rodent models. J Neurosci 39(42):8291-8304. doi: 10.1523/JNEUROSCI.3154-18.2019 PMID: 31308097

Usage: western

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Klotz L, Wendler O, Frischknecht R, Shigemoto R, Schulze H, Enz R (2019) Localization of group II and III metabotropic glutamate receptors at pre- and postsynaptic sites of inner hair cell ribbon synapses. FASEB J 33(12):13734-13746. doi: 10.1096/fj.201901543R PMID: 31585509

Usage: immunohistochemistry (1:150)

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Martins JR, Reichhart N, Kociok N, Stindl J, Foeckler R, Lachmann P, Todorov V, Castrop H, Strauß O (2019) Systemic ß adrenergic stimulation/ sympathetic nerve system stimulation influences intraocular RAS through cAMP in the RPE. Exp Eye Res 189:107828. doi: 10.1016/j.exer.2019.107828 PMID: 31589840

Objective: To investigate whether systemic β-adrenergic stimulation of the retinal pigment epithelium (RPE) also modulates renin expression in the RPE.

Summary: In vitro analysis of renin gene expression using polarized porcine RPE showed that the activity of the renin promoter can be increased by cAMP stimulation (IBMX/forskolin) but was not influenced by angiotensin-2.

Usage: Immunohistochemistry; eye sections were labeled overnight at 4°C with Anti-AT-1R.

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)