antibodies

Moreira da Silva Santos A, Gorman AM, Kelly JP, Doyle KM (2020) Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure. Neurosci Lett 715:134606. doi: 10.1016/j.neulet.2019.134606 PMID: 31693929

Objective: To investigate the effect of binge-like methamphetamine (MA) dosing on brain-derived neurotrophic factor (BDNF) levels and its receptors, trkB and p75NTR.

Summary: The binge-like regimen of MA affects expression of BDNF and its receptors, particularly the trkB receptor, in a time and region dependent manner, and highlights the importance of the frontal cortex and the striatum in the response following MA binge-like dosing.

Usage: Western blot (1:1000) NGFr (mu p75) Rabbit Polyclonal, affinity-purified

Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

Zhao Q, Zheng K, Ma C, Li J, Zhuo L, Huang W, Chen T, Jiang Y (2020) Ptps facilitates compartmentalized LTBP1 S-nitrosylation and promotes tumor growth under hypoxia. Mol Cell 77(1):95-107.e5. doi: 10.1016/j.molcel.2019.09.018 PMID: 31628042

Objective: To investigate whether there is a molecular mechanism underlying the regulation of LTBP1-TGF-b signaling by the BH4-biosynthesis pathway.

Summary: GTP cyclohydrolase I (GTPCH), 6-pyruvoyltetrahydropterin synthase (PTPS), and sepiapterin reductase (SR) are sequentially responsible for de novo synthesis of tetrahydrobiopterin (BH4), a known cofactor for nitric oxide synthase (NOS). PTPS metabolic activity is required for colorectal tumor cell growth under hypoxia.

Usage: Immunoblotting

Related Products: NO-L-Cysteine Mouse Monoclonal, Conjugated (Cat. #AB-T125)

Abbasloo E, Najafipour H, Vakili A (2020) Chronic treatment with apelin, losartan and their combination reduces myocardial infarct size and improves cardiac mechanical function. Clin Exp Pharmacol Physiol 47:393-402. doi: 10.1111/1440-1681.13195 PMID: 31630435

Objective: To determine the effect of chronic pretreatment with apelin, losartan and their combination on ischemia-reperfusion (IR) injury in the isolated perfused rat heart and on the expression of apelin-13 receptor (APJ) and angiotensin type 1 receptor (AT1R) in the myocardium.

Summary: Chronic pretreatment with apelin along with AT1R antagonist had more protective effects against IR injury.

Usage: 1:10000

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

Gao Y, Gao B, Zhu H, Yu Q, Xie F, Chen C, Li Q (2019) Adipose-derived stem cells embedded in platelet-rich plasma scaffolds improve the texture of skin grafts in a rat full-thickness wound model. Burns 46(2):377-385. doi: 10.1016/j.burns.2019.07.041 PMID: 31852618

Usage: western (1:500)

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Zhou Y (2019) PMP22 regulates lipid metabolism and cholesterol trafficking: The implication for hereditary peripheral neuropathies. University of Florida Thesis.

Objective: To study the extent of lipid abnormalities and to examine the underlying mechanisms, they determined the expression of lipid-related molecules, and studied morphological and functional alterations in the nerve, liver, and cultured cells from PMP22 KO mice.

Summary: The study reveals a novel role of PMP22 in regulating lipid metabolism and cholesterol trafficking, provide critical information for understanding the pathology of peripheral neuropathies, and shed light on the potential therapy for PMP22-linked neuropathies.

Related Products: NGFR (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

McNamara M (2019) Development of novel therapies for marfan syndrome using a human iPSC-disease model. University of Cambridge Thesis. doi: 10.17863/CAM.38053

Objective: To address different strategies that could potentially be developed into treatments of Marfan Syndrome (MFS) for the clinic.

Summary: Preliminary results show that their disease model exhibits reduced GSK3β protein expression despite GSK3β inhibition proving to be beneficial in restoring some of the phenotypic features. Further experimental efforts need to be effectuated to harness precisely the GSK3β-dependent signaling pathways that govern the phenotypic abnormalities and characterize their MFS disease model.

Usage: immunocytochemistry (1:500)

Related Products: NGFR (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

Aoyagi Y, Furuyama T, Inoue K, Matsuda D, Matsubara Y, Okahara A, Ago T, Nakashima Y, Mori M, Matsumoto T (2019) Attenuation of angiotensin II–induced hypertension in BubR1 low‐expression mice via repression of angiotensin II receptor 1 overexpression. J Am Heart Assoc 8(23):e011911. doi: 10.1161/JAHA.118.011911 PMID: 31787052

Usage: western blot

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

Lu W, Wang Q, Sun X, He H, Wang Q, Wu Y, Liu Y, Wang Y, Li C (2019) Qishen Granule improved cardiac remodeling via balancing M1 and M2 macrophages. Front Pharmacol 10:1399. doi: 10.3389/fphar.2019.01399 PMID: 31824322

Objective: To explore the effect of Qishen Granule (QSG) on the release of splenic monocytes, the recruitment of monocytes into heart tissues and the differentiation of macrophages under ischemic conditions.

Summary: Compounds of Chinese medicine have synergistic effects on cardiac and splenic organs through regulating differentiation of monocytes/macrophages in inhibiting myocardial remodeling.

Usage: Western blot

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

Li X (2019) Light stimulation into dorsal raphe nucleus contributes to antidepressant effect for a stressed rat model. bioRxiv 821421. doi: 10.1101/821421 PMID: 0

Usage: immunohisochemistry (1:500)

Related Products: Corticotropin Releasing Hormone Rabbit Polyclonal (Cat. #AB-02)

Abd El‐Rahman SS, Fayed HM (2019) Targeting AngII/AT1R signaling pathway by perindopril inhibits ongoing liver fibrosis in rat. J Tissue Eng Regen Med 13:2131-2141. doi: 10.1002/term.2940 PMID: 31348596

Usage: IHC (1:100)

Related Products: Angiotensin II receptor (AT-2R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N28AP)