RIPopedia

Dorogin J, Townsend JM, Hettiaratchi MH (2021) Biomaterials for protein delivery for complex tissue healing responses. Biomater Sci 9(7):2339-2361. doi: 10.1039/d0bm01804j

Related Products: Saporin (Cat. #PR-01)

Wensley HJ, Smith WS, Holmes SE, Flavell SU, Flavell DJ (2021) The effect of small molecule pharmacological agents on the triterpenoid saponin induced endolysosomal escape of saporin and a saporin-based immunotoxin in target human lymphoma cells. Biomedicines 9(3):300. doi: 10.3390/biomedicines9030300

Summary: Triterpenoid saponins augment the cytotoxicity of saporin based immunotoxins. It is postulated that this results from a saponin-mediated increase in the endolysosomal escape of the toxin to the cytosol. The authors used a number of pharmacological inhibitors of endocytic processes as probes to investigate the role played by saponin in the endolysosomal escape of fluorescently labeled saporin and a saporin based immunotoxin targeted against CD38 on human lymphoma and leukemia cell lines.

Shen Q, Xu L, Li R, Wu G, Li S, Saw PE, Zhou Y, Xu X (2021) A tumor microenvironment (TME)-responsive nanoplatform for systemic saporin delivery and effective breast cancer therapy. Chem Commun (Camb) 57(20):2563-2566. doi: 10.1039/d0cc07808e

Summary: This publication describes the development of a robust nanoplatform made with a TME-pH responsive Meo-PEG-b-PPMEMA polymer and a cationic lipid-like compound G0–C14 for in vivo delivery of cytotoxic saporin and breast cancer therapy.

Utterström J, Naeimipour S, Selegård R, Aili D (2021) Coiled coil-based therapeutics and drug delivery systems. Adv Drug Deliv Rev 170:26-43. doi: 10.1016/j.addr.2020.12.012

Related Products: Saporin (Cat. #PR-01)

Arslan I, Akgul H, Kara M (2021) Saporin, a polynucleotide-adenosine nucleosidase, may be an efficacious therapeutic agent for SARS-CoV-2 infection. SLAS Discov 26(3):330-335. doi: 10.1177/2472555220970911

Related Products: Saporin (Cat. #PR-01)

Liu J, Ding X, Fu Y, Xiang C, Yuan Y, Zhang Y, Yu P (2021) Cyclodextrins based delivery systems for macro biomolecules. Eur J Med Chem 212:113105. doi: 10.1016/j.ejmech.2020.113105

Related Products: Saporin (Cat. #PR-01)

See Also:

• He X et al. Simple and efficient targeted intracellular protein delivery with self-assembled nanovehicles for effective cancer therapy. Adv Funct Mater 29(50):1906187, 2019.

Chandra S, Rawat D, Bhatt A (2021) Phytochemistry and pharmacological activities of Saponaria officinalis L.: A review. Notulae Scientia Biologicae 13(1):10809. doi: 10.15835/nsb13110809

Related Products: Saporin (Cat. #PR-01)

Duarte L, Alexandre M, Chaves A, Santos D, deSouza A, Bernacci L (2021) Plant-virus infection inhibitors: The great potential of Caryophyllales species. Physiol Mol Plant Pathol 113:101597. doi: 10.1016/j.pmpp.2020.101597

Related Products: Saporin (Cat. #PR-01)

Nakase I (2020) Intracellular delivery methods using biofunctional peptide-modified extracellular vesicles. Extracell Vesicles Circ Nucleic Acids 1:44. American Society for Exosomes and Microvesicles 2020 Annual Meeting. doi: 10.20517/evcna.2020.10

Related Products: Saporin (Cat. #PR-01)

Pazo M, Salluce G, Lostalé-Seijo I, Juanes M, Gonzalez F, Garcia-Fandiño R, Montenegro J (2021) Short oligoalanine helical peptides for supramolecular nanopore assembly and protein cytosolic delivery. RSC Chem Biol 2:503-512. doi: 10.1039/D0CB00103A

Related Products: Saporin (Cat. #PR-01)