- Home
- Knowledge Base
- RIPopedia
RIPopedia
Biomaterials for protein delivery for complex tissue healing responses
Dorogin J, Townsend JM, Hettiaratchi MH (2021) Biomaterials for protein delivery for complex tissue healing responses. Biomater Sci 9(7):2339-2361. doi: 10.1039/d0bm01804j
Related Products: Saporin (Cat. #PR-01)
The effect of small molecule pharmacological agents on the triterpenoid saponin induced endolysosomal escape of saporin and a saporin-based immunotoxin in target human lymphoma cells
Wensley HJ, Smith WS, Holmes SE, Flavell SU, Flavell DJ (2021) The effect of small molecule pharmacological agents on the triterpenoid saponin induced endolysosomal escape of saporin and a saporin-based immunotoxin in target human lymphoma cells. Biomedicines 9(3):300. doi: 10.3390/biomedicines9030300
Summary: Triterpenoid saponins augment the cytotoxicity of saporin based immunotoxins. It is postulated that this results from a saponin-mediated increase in the endolysosomal escape of the toxin to the cytosol. The authors used a number of pharmacological inhibitors of endocytic processes as probes to investigate the role played by saponin in the endolysosomal escape of fluorescently labeled saporin and a saporin based immunotoxin targeted against CD38 on human lymphoma and leukemia cell lines.
A tumor microenvironment (TME)-responsive nanoplatform for systemic saporin delivery and effective breast cancer therapy
Shen Q, Xu L, Li R, Wu G, Li S, Saw PE, Zhou Y, Xu X (2021) A tumor microenvironment (TME)-responsive nanoplatform for systemic saporin delivery and effective breast cancer therapy. Chem Commun (Camb) 57(20):2563-2566. doi: 10.1039/d0cc07808e
Summary: This publication describes the development of a robust nanoplatform made with a TME-pH responsive Meo-PEG-b-PPMEMA polymer and a cationic lipid-like compound G0–C14 for in vivo delivery of cytotoxic saporin and breast cancer therapy.
Saporin, a polynucleotide-adenosine nucleosidase, may be an efficacious therapeutic agent for SARS-CoV-2 infection
Arslan I, Akgul H, Kara M (2021) Saporin, a polynucleotide-adenosine nucleosidase, may be an efficacious therapeutic agent for SARS-CoV-2 infection. SLAS Discov 26(3):330-335. doi: 10.1177/2472555220970911
Related Products: Saporin (Cat. #PR-01)
Coiled coil-based therapeutics and drug delivery systems
Utterström J, Naeimipour S, Selegård R, Aili D (2021) Coiled coil-based therapeutics and drug delivery systems. Adv Drug Deliv Rev 170:26-43. doi: 10.1016/j.addr.2020.12.012
Related Products: Saporin (Cat. #PR-01)
Cyclodextrins based delivery systems for macro biomolecules
Liu J, Ding X, Fu Y, Xiang C, Yuan Y, Zhang Y, Yu P (2021) Cyclodextrins based delivery systems for macro biomolecules. Eur J Med Chem 212:113105. doi: 10.1016/j.ejmech.2020.113105
Related Products: Saporin (Cat. #PR-01)
See Also:
Phytochemistry and pharmacological activities of Saponaria officinalis L.: A review
Chandra S, Rawat D, Bhatt A (2021) Phytochemistry and pharmacological activities of Saponaria officinalis L.: A review. Notulae Scientia Biologicae 13(1):10809. doi: 10.15835/nsb13110809
Related Products: Saporin (Cat. #PR-01)
Plant-virus infection inhibitors: The great potential of Caryophyllales species
Duarte L, Alexandre M, Chaves A, Santos D, deSouza A, Bernacci L (2021) Plant-virus infection inhibitors: The great potential of Caryophyllales species. Physiol Mol Plant Pathol 113:101597. doi: 10.1016/j.pmpp.2020.101597
Related Products: Saporin (Cat. #PR-01)
Intracellular delivery methods using biofunctional peptide-modified extracellular vesicles
Nakase I (2020) Intracellular delivery methods using biofunctional peptide-modified extracellular vesicles. Extracell Vesicles Circ Nucleic Acids 1:44. American Society for Exosomes and Microvesicles 2020 Annual Meeting. doi: 10.20517/evcna.2020.10
Related Products: Saporin (Cat. #PR-01)
Short oligoalanine helical peptides for supramolecular nanopore assembly and protein cytosolic delivery
Pazo M, Salluce G, Lostalé-Seijo I, Juanes M, Gonzalez F, Garcia-Fandiño R, Montenegro J (2021) Short oligoalanine helical peptides for supramolecular nanopore assembly and protein cytosolic delivery. RSC Chem Biol 2:503-512. doi: 10.1039/D0CB00103A
Related Products: Saporin (Cat. #PR-01)