RIPopedia

Ahmad A, Khan JM (2022) pH-sensitive endosomolytic peptides in gene and drug delivery: Endosomal escape and current challenges. Journal of Drug Delivery Science and Technology 76:103786. doi: 10.1016/j.jddst.2022.103786

Objective: To provide an overview on mechanism of endosomal escape of pH-sensitive endosomolytic peptides.

Summary: Discussion topics: the many forms of anionic and cationic pH-sensitive endosomolytic peptides (pSEPs) employed in gene/drug delivery for endosomal escape enhancement, the mechanisms by which pSEPs escape the endosome.

Iglesias R, Russo R, Landi N, Valletta M, Chambery A, Di Maro A, Bolognesi A, Ferreras JM, Citores L (2022) Structure and biological properties of ribosome-inactivating proteins and lectins from elder (Sambucus nigra L.) leaves. Toxins 14(9):611. doi: 10.3390/toxins14090611

Summary: This work contributes to expanding our knowledge of the family of RIPs and RIP-related lectins produced by Sambucus nigra, with eight new proteins found in leaves: one type 2 RIP and two related lectins that are specific for galactose, four type 2 RIPs with deficient sugar binding domains and one type 1 RIP. This knowledge is important for the potential medical and biotechnological use of these proteins.

Other Information: 3CA5: Sambucus nigra agglutinin II (SNA-II)-tetragonal crystal form-complexed to alpha1 methylgalactose

https://www.rcsb.org/3d-view/3CA5/1

Salvioni L, Testa F, Barbieri L, Giustra M, Bertolini JA, Tomaino G, Tortora P, Prosperi D, Colombo M (2022) Saporin toxin delivered by engineered colloidal nanoparticles is strongly effective against cancer cells. Pharmaceutics 14(7):1517. doi: 10.3390/pharmaceutics14071517

Zuppone S, Assalini C, Minici C, Botrugno OA, Curnis F, Degano M, Corti A, Montorsi F, Salonia A, Vago R (2022) A novel RGD-4C-saporin conjugate inhibits tumor growth in mouse models of bladder cancer. Front Oncol 12:846958. doi: 10.3389/fonc.2022.846958

Yan Y, Zhou L, Sun Z, Song D, Cheng Y (2021) Targeted and intracellular delivery of protein therapeutics by a boronated polymer for the treatment of bone tumors. Bioact Mater 7:333-340. doi: 10.1016/j.bioactmat.2021.05.041

Yu M, Liu X, Cheng H, Kuang L, Zhang S, Yan X (2021) Latest progress in the study of nanoparticle-based delivery of the CRISPR/Cas9 system. Methods 194:48-55. doi: 10.1016/j.ymeth.2021.06.004

Related Products: Saporin (Cat. #PR-01)

Lointier M, Dussouillez C, Glattard E, Kichler A, Bechinger B (2021) Different biological activities of histidine-rich peptides are favored by variations in their design. Toxins (Basel) 13(5):363. doi: 10.3390/toxins13050363

Related Products: Saporin (Cat. #PR-01)

Kawasaki R, Sasaki Y, Nishimura T, Katagiri K, Morita KI, Sekine Y, Sawada SI, Mukai SA, Akiyoshi K (2021) Magnetically navigated protein transduction in vivo using iron oxide-nanogel chaperone hybrid. Adv Healthc Mater 10(9):e2001988. doi: 10.1002/adhm.202001988

Summary: A magnetically guided in vivo protein transduction is demonstrated using magnetic nanogel chaperone (MC) composed of iron oxide nanoparticles and a polysaccharide nanogel, a protein carrier inspired by “catch and release” mechanisms of MCs. In an oral cancer model, MC-delivered magnetically targeted saporin decreased tumor volume without significant body weight changes and no regrowth of tumor at 3 months after complete regression.

Polito L, Bortolotti M, Iglesias R, Bolognesi A (2021) Editorial: Toxic plant proteins as experimental drugs for human pathologies. Front Pharmacol 12:689924. doi: 10.3389/fphar.2021.689924

Related Products: Saporin (Cat. #PR-01)

di Leandro L, Giansanti F, Mei S, Ponziani S, Colasante M, Ardini M, Angelucci F, Pitari G, d’Angelo M, Cimini A, Fabbrini MS, Ippoliti R (2021) Aptamer-driven toxin gene delivery in U87 model glioblastoma cells. Front Pharmacol 12:588306. doi: 10.3389/fphar.2021.588306

Related Products: Saporin (Cat. #PR-01)