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Magnetically navigated protein transduction in vivo using iron oxide-nanogel chaperone hybrid

Kawasaki R, Sasaki Y, Nishimura T, Katagiri K, Morita KI, Sekine Y, Sawada SI, Mukai SA, Akiyoshi K (2021) Magnetically navigated protein transduction in vivo using iron oxide-nanogel chaperone hybrid. Adv Healthc Mater 10(9):e2001988. doi: 10.1002/adhm.202001988

Summary: A magnetically guided in vivo protein transduction is demonstrated using magnetic nanogel chaperone (MC) composed of iron oxide nanoparticles and a polysaccharide nanogel, a protein carrier inspired by “catch and release” mechanisms of MCs. In an oral cancer model, MC-delivered magnetically targeted saporin decreased tumor volume without significant body weight changes and no regrowth of tumor at 3 months after complete regression.

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