References

Sitrin RG, Todd RF 3rd, Albrecht E, Gyetko MR (1996) The urokinase receptor (CD87) facilitates CD11b/CD18-mediated adhesion of human monocytes. J Clin Invest 97(8):1942-1951. doi: 10.1172/JCI118626 PMID: 8621779

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Trickle K, Dornan W (1996) The “combined” 192 IGG saporin lesion approach as an anima model of alzheimer’s disease. Illinois Wesleyan Univ Thesis.

Objective: Provide evidence that injections of 192-IgG-SAP both in the medial septal area and the nucleus basalis magnocellularis creates a reliable animal model of Alzheimer’s disease (AD).

Summary: 192-IgG-SAP (IT-01) is a selective cholinergic neurotoxin. Intraventricular injections of 192-IgG-SAP into the lateral ventricles induced a 80-90% reduction of acetylcholine levels in the cortex and hippocampus. Although studies have reported an impairment of spatial learning following treatment by 192-IgG-SAP, the effects observed may be due to loss of cerebellar Purkinje cells following intraventricular injection (i.c.v.). Authors propose that through a combined medial septum and nucleus basalis magnocellularis lesioning technique, a model for AD can be created in a rat that better reflects only damage to strictly cholinergic cells in the impacted regions of the brain.

Usage: Animals received three injections of 192-IgG-SAP into the medial septal area and two (bilateral) injections into the nucleus basalis magnocellularis.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Nicholson LB, Vlase H, Graves P, Nilsson M, Molne J, Huang GC, Morgenthaler NG, Davies TF, McGregor AM, Banga JP (1996) Monoclonal antibodies to the human TSH receptor: epitope mapping and binding to the native receptor on the basolateral plasma membrane of the thyroid follicular cells. J Mol Endocrinol 16:159-170. doi: 10.1677/jme.0.0160159 PMID: 9156519

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McGaughy J, Kaiser T, Sarter M (1996) Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density. Behav Neurosci 110:247-265. doi: 10.1037//0735-7044.110.2.247 PMID: 8731052

Usage: Rats were administered 0.5 ul of 192-IgG-SAP (0.21 ug/0.5 ul) bilaterally within the basal forebrain.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Wiley RG (1996) Targeting toxins to neural antigens and receptors. Semin Cancer Biol 7(2):71-77. doi: 10.1006/scbi.1996.0011 PMID: 8740562

Jouvenceau A, Billard JM, Lamour Y, Dutar P (1996) Persistence of CA1 hippocampal LTP after selective cholinergic denervation. NeuroReport 7(4):948-952. doi: 10.1097/00001756-199603220-00024

Related Products: 192-IgG-SAP (Cat. #IT-01)

Kapas L, Obal Jr, F, Book AA, Schweitzer JB, Wiley RG, Krueger JM (1996) The effects of immunolesions of nerve growth factor-receptive neurons by 192 IgG-saporin on sleep. Brain Res 712:53-59. doi: 10.1016/0006-8993(95)01431-4

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Bykowsky MJ, Haire RN, Ohta Y, Tang H, Sung SS, Veksler ES, Greene JM, Fu SM, Litman GW, Sullivan KE (1996) Discordant phenotype in siblings with X-linked agammaglobulinemia. Am J Hum Genet 58(3):477-483. PMID: 8644706

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Vnek N, Kromer LF, Wiley RG, Rothblat LA (1996) The basal forebrain cholinergic system and object memory in the rat. Brain Res 710:265-270. doi: 10.1016/0006-8993(95)01477-2

Related Products: 192-IgG-SAP (Cat. #IT-01)

Hage B, Frotscher M, Naumann T (1996) Activity of choline acetyltransferase in the rat medial septal nucleus following fimbria-fornix transection or selective immunolesioning with 192 IgG-saporin. Neurosci Lett 205:119-122. doi: 10.1016/0304-3940(96)12392-2

Related Products: 192-IgG-SAP (Cat. #IT-01)